0B68 Covarrubias, Manuel - Thomas Jefferson University - Thomas Jefferson University

Manuel Covarrubias, MD, PhD

Contact Dr. Covarrubias

900 Walnut St.
Suite 400
Philadelphia, PA 19107

(215) 503-4341
(215) 955-4949 fax

Most Recent Peer-reviewed Publications

  1. Role for the Propofol Hydroxyl in Anesthetic Protein Target Molecular Recognition
  2. Dysregulation of Kv3.4 channels in dorsal root ganglia following spinal cord injury
  3. Modulation of a voltage-gated Na+ channel by sevoflurane involves multiple sites and distinct mechanisms
  4. Insight into the modulation of Shaw2 Kv channels by general anesthetics: Structural and functional studies of S4-S5 linker and S6 C-terminal peptides in micelles by NMR
  5. Alcohol and anesthetic action at the gate of a voltage-dependent K+ channel
  6. Molecular physiology and modulation of somatodendritic A-type potassium channels
  7. Allosteric modulation of a neuronal K+ channel by 1-alkanols is linked to a key residue in the activation gate
  8. Molecular features of an alcohol binding site in a neuronal potassium channel
  9. The link between ion permeation and inactivation gating of Kv4 potassium channels
  10. Remodelling inactivation gating of Kv4 channels by KChIP1, a small-molecular-weight calcium-binding protein
  11. Elimination of fast inactivation in Kv4 A-type potassium channels by an auxiliary subunit domain
  12. Kv4 channels exhibit modulation of closed-state inactivation in inside-out patches
  13. Potent inhibition of the aortic smooth muscle maxi-K channel by clinical doses of ethanol
  14. General anesthetic action at an internal protein site involving the S4- S5 cytoplasmic loop of a neuronal K+ channel
  15. Inactivation gating of Kv4 potassium channels: Molecular interactions involving the inner vestibule of the pore
  16. Injection of Xenopus oocytes with mRNA from cultured neurons induces new currents and susceptibility to the damaging action of ruthenium red
  17. Receptor-coupled regulation of K+ channel N-type inactivation
  18. Interactions between multiple phosphorylation sites in the inactivation particle of a K+ channel: Insights into the molecular mechanism of protein kinase C action
  19. K+ channel inactivation mediated by the concerted action of the cytoplasmic N- and C-terminal domains
  20. Alcohols inhibit a cloned potassium channel at a discrete saturable site: Insights into the molecular basis of general anesthesia