mlc105

Manuel Covarrubias, MD, PhD

Contact Dr. Covarrubias

900 Walnut Street
JHN 4th floor
Philadelphia, PA 19107

(215) 503-4340
(215) 503-4358 fax

Most Recent Peer-reviewed Publications

  1. Photoaffinity Ligand for the Inhalational Anesthetic Sevoflurane Allows Mechanistic Insight into Potassium Channel Modulation
  2. Sites and Functional Consequence of Alkylphenol Anesthetic Binding to Kv1.2 Channels
  3. A novel bifunctional alkylphenol anesthetic allows characterization of γ-aminobutyric acid, type A (GABAA), receptor subunit binding selectivity in synaptosomes
  4. Closed-state inactivation involving an internal gate in Kv4.1 channels modulates pore blockade by intracellular quaternary ammonium ions
  5. Mechanistic Insights into the Modulation of Voltage-Gated Ion Channels by Inhalational Anesthetics
  6. Positive allosteric modulation of Kv channels by sevoflurane: Insights into the structural basis of inhaled anesthetic action
  7. Role for the Propofol Hydroxyl in Anesthetic Protein Target Molecular Recognition
  8. Kv3.4 channel function and dysfunction in nociceptors
  9. Dysregulation of Kv3.4 channels in dorsal root ganglia following spinal cord injury
  10. Modulation of a voltage-gated Na+ channel by sevoflurane involves multiple sites and distinct mechanisms
  11. Dipeptidyl-peptidase-like proteins cast in a new role: Enabling scorpion toxin block of A-type K+ channels
  12. Insight into the modulation of Shaw2 Kv channels by general anesthetics: Structural and functional studies of S4-S5 linker and S6 C-terminal peptides in micelles by NMR
  13. Modeling-independent elucidation of inactivation pathways in recombinant and native A-type Kv channels
  14. Novel activation of voltage-gated K+ channels by sevoflurane
  15. Modulation of Kv3.4 channel N-type inactivation by protein kinase C shapes the action potential in dorsal root ganglion neurons
  16. Molecular mapping of general anesthetic sites in a voltage-gated ion channel
  17. Cortactin is required for N-cadherin regulation of Kv1.5 channel function
  18. Mechanisms of closed-state inactivation in voltage-gated ion channels
  19. Simulating complex ion channel kinetics with IonChannelLab.
  20. Azi-isoflurane, a photolabel analog of the commonly used inhaled general anesthetic isoflurane