2960 Covarrubias, Manuel - Thomas Jefferson University - Thomas Jefferson University
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Manuel Covarrubias, MD, PhD

Contact Dr. Covarrubias

900 Walnut Street
JHN 4th floor
Philadelphia, PA 19107

(215) 503-4340
(215) 503-4358 fax

Most Recent Peer-reviewed Publications

  1. Mechanistic Insights into the Modulation of Voltage-Gated Ion Channels by Inhalational Anesthetics
  2. Positive allosteric modulation of Kv channels by sevoflurane: Insights into the structural basis of inhaled anesthetic action
  3. Role for the Propofol Hydroxyl in Anesthetic Protein Target Molecular Recognition
  4. Dysregulation of Kv3.4 channels in dorsal root ganglia following spinal cord injury
  5. Kv3.4 channel function and dysfunction in nociceptors
  6. Modulation of a voltage-gated Na+ channel by sevoflurane involves multiple sites and distinct mechanisms
  7. Insight into the modulation of Shaw2 Kv channels by general anesthetics: Structural and functional studies of S4-S5 linker and S6 C-terminal peptides in micelles by NMR
  8. Azi-isoflurane, a photolabel analog of the commonly used inhaled general anesthetic isoflurane
  9. Inhalational anaesthetics and n-alcohols share a site of action in the neuronal Shaw2 K v channel: Research paper
  10. A novel N-terminal motif of dipeptidyl peptidase-like proteins produces rapid inactivation of KV4.2 channels by a pore-blocking mechanism
  11. Kv4 channels underlie the subthreshold-operating A-type K+-current in nociceptive dorsal root ganglion neurons
  12. The dipeptidyl-peptidase-like protein DPP6 determines the unitary conductance of neuronal Kv4.2 channels
  13. The dipeptidyl-aminopeptidase-like protein 6 is an integral voltage sensor-interacting β-subunit of neuronal KV4.2 channels
  14. The neuronal Kv4 channel complex
  15. NMR analysis of KChIP4a reveals structural basis for control of surface expression of Kv4 channel complexes
  16. Ternary Kv4.2 channels recapitulate voltage-dependent inactivation kinetics of A-type K+ channels in cerebellar granule neurons
  17. Gating charge immobilization in Kv4.2 channels: The basis of closed-state inactivation
  18. Mechanism of the modulation of Kv4:KChIP-1 channels by external K
  19. Cumulative activation of voltage-dependent KVS-1 potassium channels
  20. Zn2+-dependent redox switch in the intracellular T1-T1 interface of a Kv channel
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