27EC Pasinelli, Piera - Thomas Jefferson University - Thomas Jefferson University
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Piera Pasinelli, PhD

Contact Dr. Pasinelli

900 Walnut St.
Suite 451F
Philadelphia, PA 19107

(215) 955-8394
(215) 503-9128 fax

Most Recent Peer-reviewed Publications

  1. Role of mitochondria in mutant SOD1 linked amyotrophic lateral sclerosis
  2. Sumoylation of the astroglial glutamate transporter EAAT2 governs its intracellular compartmentalization
  3. Defects in synapse structure and function precede motor neuron degeneration in Drosophila models of FUS-related ALS
  4. Small peptides against the mutant SOD1/Bcl-2 toxic mitochondrial complex restore mitochondrial function and cell viability in mutant SOD1-mediated ALS
  5. Selective increase of two ABC drug efflux transporters at the blood-spinal cord barrier suggests induced pharmacoresistance in ALS
  6. An over-oxidized form of superoxide dismutase found in sporadic amyotrophic lateral sclerosis with bulbar onset shares a toxic mechanism with mutant SOD1
  7. Motor neuron impairment mediated by a sumoylated fragment of the glial glutamate transporter EAAT2
  8. In vivo and in vitro determination of cell death markers in neurons
  9. Wild-type and mutant SOD1 share an aberrant conformation and a common pathogenic pathway in ALS
  10. Voltage-dependent inwardly rectifying potassium conductance in the outer membrane of neuronal mitochondria
  11. ALS-linked mutant SOD1 damages mitochondria by promoting conformational changes in Bcl-2
  12. Nordihydroguaiaretic acid increases glutamate uptake in vitro and in vivo: Therapeutic implications for amyotrophic lateral sclerosis
  13. A caspase-3-cleaved fragment of the glial glutamate transporter EAAT2 is sumoylated and targeted to promyelocytic leukemia nuclear bodies in mutant SOD1-linked amyotrophic lateral sclerosis
  14. The proapoptotic BCL-2 family member BIM mediates motoneuron loss in a model of amyotrophic lateral sclerosis
  15. Molecular biology of amyotrophic lateral sclerosis: Insights from genetics
  16. Caspase-3 cleaves and inactivates the glutamate transporter EAAT2
  17. Inhibition of SOD1 expression by mitomycin C is a non-specific consequence of cellular toxicity
  18. Amyotrophic lateral sclerosis-associated SOD1 mutant proteins bind and aggregate with Bcl-2 in spinal cord mitochondria
  19. Prophylactic creatine administration mediates neuroprotection in cerebral ischemia in mice
  20. Molecular signature of late-stage human ALS revealed by expression profiling of postmortem spinal cord gray matter
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