2238 Pasinelli, Piera - Thomas Jefferson University - Thomas Jefferson University
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Piera Pasinelli, PhD

Contact Dr. Pasinelli

900 Walnut Street
JHN 4th floor
Philadelphia, PA 19107

(215) 955-8394
(215) 503-4358 fax

Most Recent Peer-reviewed Publications

  1. Astrocytes drive upregulation of the multidrug resistance transporter ABCB1 (P-Glycoprotein) in endothelial cells of the blood–brain barrier in mutant superoxide dismutase 1-linked amyotrophic lateral sclerosis
  2. Pur-alpha regulates cytoplasmic stress granule dynamics and ameliorates FUS toxicity
  3. Astrocytes drive upregulation of the multidrug resistance transporter ABCB1 (P-Glycoprotein) in endothelial cells of the blood-brain barrier in mutant superoxide dismutase 1-linked amyotrophic lateral sclerosis
  4. Regulation of ABC efflux transporters at blood-brain barrier in health and neurological disorders
  5. Role of mitochondria in mutant SOD1 linked amyotrophic lateral sclerosis
  6. Sumoylation of the astroglial glutamate transporter EAAT2 governs its intracellular compartmentalization
  7. Antisense proline-arginine RAN dipeptides linked to C9ORF72-ALS/FTD form toxic nuclear aggregates that initiate invitro and invivo neuronal death
  8. Antisense proline-arginine RAN dipeptides linked to C9ORF72-ALS/FTD form toxic nuclear aggregates that initiate in vitro and in vivo neuronal death
  9. Defects in synapse structure and function precede motor neuron degeneration in Drosophila models of FUS-related ALS
  10. Small peptides against the mutant SOD1/Bcl-2 toxic mitochondrial complex restore mitochondrial function and cell viability in mutant SOD1-mediated ALS
  11. Selective increase of two ABC drug efflux transporters at the blood-spinal cord barrier suggests induced pharmacoresistance in ALS
  12. An over-oxidized form of superoxide dismutase found in sporadic amyotrophic lateral sclerosis with bulbar onset shares a toxic mechanism with mutant SOD1
  13. Motor neuron impairment mediated by a sumoylated fragment of the glial glutamate transporter EAAT2
  14. In vivo and in vitro determination of cell death markers in neurons
  15. Wild-type and mutant SOD1 share an aberrant conformation and a common pathogenic pathway in ALS 0939
  16. Voltage-dependent inwardly rectifying potassium conductance in the outer membrane of neuronal mitochondria
  17. ALS-linked mutant SOD1 damages mitochondria by promoting conformational changes in Bcl-2
  18. Nordihydroguaiaretic acid increases glutamate uptake in vitro and in vivo: Therapeutic implications for amyotrophic lateral sclerosis
  19. A caspase-3-cleaved fragment of the glial glutamate transporter EAAT2 is sumoylated and targeted to promyelocytic leukemia nuclear bodies in mutant SOD1-linked amyotrophic lateral sclerosis
  20. The proapoptotic BCL-2 family member BIM mediates motoneuron loss in a model of amyotrophic lateral sclerosis
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