Hui Zhang, PhD
Philadelphia, PA 19107
Most Recent Peer-reviewed Publications
- Fluorescent dopamine tracer resolves individual dopaminergic synapses and their activity in the brain
- Regulation of striatal dopamine release by presynaptic auto- and heteroreceptors
- Vesicular Glutamate Transport Promotes Dopamine Storage and Glutamate Corelease In Vivo
- Dopamine release at individual presynaptic terminals visualized with FFNs.
- Dopamine release at individual presynaptic terminals visualized with FFNs
Expertise and Research Interests
Research in my laboratory aims to elucidate the pathogenic mechanisms of Parkinson's disease and Schizophrenia at the molecular, cellular and synaptic levels. Much effort is directed at the striatum, the input nucleus of the basal ganglia and the prefrontal cortex, a cortical region which plays a central role in cognition. We employ a combination of electrochemical, electrophysiological, optical imaging, optogenetics, and genetic approaches to explore the plasticity of dopamine neurotransmission, the role of dopamine in modulating information flow and how the process is disturbed in these disorders. In addition, we are developing optical tools to study whether dopamine dys-regulation in schizophrenia is in part due to intrinsic changes in the presynaptic dopamine terminals.
- The pathophysiology of Parkinson's disease: LRRK2 mediated pathogenic pathways in dopaminergic axonal degeneration and synaptic transmission
- Dopamine neurotransmission and modulation of the prefrontal cortex in mouse models of schizophrenia
- The role of tonic and phasic dopamine signaling in the striatum