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Maurizio Pacifici, PhD

Contact Dr. Pacifici

Children's Hospital of Philadelphia
3400 Civic Center Boulevard
Philadelphia, PA 19104

(215) 955-7352
(215) 955-9159 fax

Most Recent Peer-reviewed Publications

  1. Hereditary Multiple Exostoses: New Insights into Pathogenesis, Clinical Complications, and Potential Treatments
  2. Cell origin, volume and arrangement are drivers of articular cartilage formation, morphogenesis and response to injury in mouse limbs
  3. Genetic and pharmacological inhibition of retinoic acid receptor γ function promotes endochondral bone formation
  4. Unsuspected osteochondroma-like outgrowths in the cranial base of Hereditary Multiple Exostoses patients and modeling and treatment with a BMP antagonist in mice
  5. Epiprofin Regulates Enamel Formation and Tooth Morphogenesis by Controlling Epithelial-Mesenchymal Interactions During Tooth Development
  6. Retinoid roles and action in skeletal development and growth provide the rationale for an ongoing heterotopic ossification prevention trial
  7. Assessing the general population frequency of rare coding variants in the EXT1 and EXT2 genes previously implicated in hereditary multiple exostoses
  8. Effectiveness and mode of action of a combination therapy for heterotopic ossification with a retinoid agonist and an anti-inflammatory agent
  9. Palovarotene Inhibits Heterotopic Ossification and Maintains Limb Mobility and Growth in Mice With the Human ACVR1R206H Fibrodysplasia Ossificans Progressiva (FOP) Mutation
  10. Targeted stimulation of retinoic acid receptor-γ mitigates the formation of heterotopic ossification in an established blast-related traumatic injury model
  11. HhAntag, a Hedgehog Signaling Antagonist, Suppresses Chondrogenesis and Modulates Canonical and Non-Canonical BMP Signaling
  12. Osteophyte formation and matrix mineralization in a TMJ osteoarthritis mouse model are associated with ectopic hedgehog signaling
  13. Excess BMP Signaling in Heterotopic Cartilage Forming in Prg4 -null TMJ Discs
  14. Common mutations in ALK2/ACVR1, a multi-faceted receptor, have roles in distinct pediatric musculoskeletal and neural orphan disorders
  15. Delayed hypertrophic differentiation of epiphyseal chondrocytes contributes to failed secondary ossification in mucopolysaccharidosis VII dogs
  16. Articular cartilage endurance and resistance to osteoarthritic changes require transcription factor Erg
  17. Articular Cartilage: Structural and Developmental Intricacies and Questions
  18. Interactions of signaling proteins, growth factors and other proteins with heparan sulfate: Mechanisms and mysteries
  19. Heparanase stimulates chondrogenesis and is up-regulated in human ectopic cartilage: A mechanism possibly involved in hereditary multiple exostoses
  20. The type 2 diabetes associated rs7903146 T allele within TCF7L2 is significantly under-represented in Hereditary Multiple Exostoses: Insights into pathogenesis