0B68 Risbud, Makarand V. - Thomas Jefferson University - Thomas Jefferson University
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Makarand V. Risbud, PhD

Contact Dr. Risbud

1015 Walnut Street
Suite 501, Curtis Bldg.
Philadelphia, PA 19107


Most Recent Peer-reviewed Publications

  1. Defining the phenotype of young healthy nucleus pulposus cells: Recommendations of the Spine Research Interest Group at the 2014 annual ORS meeting
  2. Loss of HIF-1α in the notochord results in cell death and complete disappearance of the nucleus pulposus
  3. FIH-1-Mint3 axis does not control HIF-1α transcriptional activity in nucleus pulposus cells
  4. CCN2 suppresses catabolic effects of interleukin-1β through α5β1 and αVβ3 Integrins in nucleus pulposus cells: Implications in intervertebral disc degeneration
  5. HIF-1-PHD2 axis controls expression of syndecan 4 in nucleus pulposus cells
  6. Tumor necrosis factor-α- and interleukin-1β-dependent matrix metalloproteinase-3 expression in nucleus pulposus cells requires cooperative signaling via syndecan 4 and mitogen-activated protein kinase-NF-κB axis: Implications in inflammatory disc disease
  7. Role of cytokines in intervertebral disc degeneration: Pain and disc content
  8. Extracellular osmolarity regulates matrix homeostasis in the intervertebral disc and articular cartilage: Evolving role of TonEBP
  9. Xylosyltransferase-1 expression is refractory to inhibition by the inflammatory cytokines tumor necrosis factor α and IL-1β in nucleus pulposus cells: Novel regulation by AP-1, Sp1, and Sp3
  10. Substance p stimulates production of inflammatory cytokines in human disc cells
  11. An organ culture system to model early degenerative changes of the intervertebral disc II: Profiling global gene expression changes
  12. Molecular regulation of CCN2 in the intervertebral disc: Lessons learned from other connective tissues
  13. Inflammatory cytokines induce NOTCH signaling in nucleus pulposus cells: Implications in intervertebral disc degeneration
  14. Inflammatory cytokines associated with degenerative disc disease control aggrecanase-1 (ADAMTS-4) expression in nucleus pulposus cells through MAPK and NF-κB
  15. Expression and relationship of proinflammatory chemokine RANTES/CCL5 and cytokine IL-1 β in painful human intervertebral discs
  16. Hypoxia-inducible factor (HIF)-1α and CCN2 form a regulatory circuit in hypoxic nucleus pulposus cells: CCN2 suppresses HIF-1α level and transcriptional activity
  17. The molecular basis of intervertebral disc degeneration
  18. Tumor necrosis factor α- And interleukin-1β-dependent induction of CCL3 expression by nucleus pulposus cells promotes macrophage migration through CCR1
  19. Exhaustion of nucleus pulposus progenitor cells with ageing and degeneration of the intervertebral disc
  20. Prolyl hydroxylase 3 (PHD3) modulates catabolic effects of tumor necrosis factor-α (TNF-α) on cells of the nucleus pulposus through co-activation of nuclear factor κB (NF-κB)/p65 signaling
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