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Irving M. Shapiro, BDS, PhD

Contact Dr. Shapiro

1015 Walnut Street
Curtis Building, Suite 501
Philadelphia, PA 19107

(215) 955-7217
(215) 955-9159 fax

Most Recent Peer-reviewed Publications

  1. Lack of evidence for involvement of TonEBP and hyperosmotic stimulus in induction of autophagy in the nucleus pulposus
  2. PHD3 is a transcriptional coactivator of HIF-1a in nucleus pulposus cells independent of the PKM2-JMJD5 axis
  3. TNF-α promotes nuclear enrichment of the transcription factor TonEBP/NFAT5 to selectively control inflammatory but not osmoregulatory responses in nucleus pulposus cells
  4. RNA sequencing reveals a role of TonEBP transcription factor in regulation of pro-inflammatory genes in response to hyperosmolarity in healthy nucleus pulposus cells a homeostatic response?
  5. Hypoxia promotes noncanonical autophagy in nucleus pulposus cells independent of MTOR and HIF1A signaling
  6. Class i and IIa HDACs Mediate HIF-1α Stability Through PHD2-Dependent Mechanism, while HDAC6, a Class IIb Member, Promotes HIF-1α Transcriptional Activity in Nucleus Pulposus Cells of the Intervertebral Disc
  7. Syndecan-4 in intervertebral disc and cartilage: Saint or synner?
  8. Circadian factors BMAL1 and RORα control HIF-1α transcriptional activity in nucleus pulposus cells: Implications in maintenance of intervertebral disc health
  9. TGFβ regulates Galectin-3 expression through canonical Smad3 signaling pathway in nucleus pulposus cells: Implications in intervertebral disc degeneration
  10. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
  11. Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356
  12. Matrix vesicles: Are they anchored exosomes?
  13. Porphyrin-adsorbed Allograft Bone: A Photoactive, Antibiofilm Surface
  14. The proteasome inhibitor carfilzomib suppresses parathyroid hormone-induced osteoclastogenesis through a RANKL-mediated signaling pathway
  15. Staphylococcal persistence due to biofilm formation in synovial fluid containing prophylactic cefazolin
  16. Prolyl-4-hydroxylase domain protein 2 controls NF-κB/p65 transactivation and enhances the catabolic effects of inflammatory cytokines on cells of the nucleus pulposus
  17. Capturing Orthopaedic Surgical Site Infection Data and Assessing Dental Recommendations with Respect to Total Joint Arthroplasty
  18. Discovery of the drivers of inflammation induced chronic low back pain: From bacteria to diabetes
  19. Effect of biofilms on recalcitrance of staphylococcal joint infection to antibiotic treatment
  20. Disc in flames: Roles of TNF-α and IL-1β in intervertebral disc degeneration