2ACE Shapiro, Irving M. - Thomas Jefferson University - Thomas Jefferson University
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Irving M. Shapiro, BDS, PhD

Contact Dr. Shapiro

1015 Walnut Street
Curtis Building, Suite 501
Philadelphia, PA 19107

(215) 955-7217
(215) 955-9159 fax

Most Recent Peer-reviewed Publications

  1. Loss of HIF-1α in the notochord results in cell death and complete disappearance of the nucleus pulposus
  2. FIH-1-Mint3 axis does not control HIF-1α transcriptional activity in nucleus pulposus cells
  3. CCN2 suppresses catabolic effects of interleukin-1β through α5β1 and αVβ3 Integrins in nucleus pulposus cells: Implications in intervertebral disc degeneration
  4. Prosthesis Selection
  5. Prosthesis selection
  6. HIF-1-PHD2 axis controls expression of syndecan 4 in nucleus pulposus cells
  7. Boning up on autophagy :The role of autophagy in skeletal biology
  8. Tumor necrosis factor-α- and interleukin-1β-dependent matrix metalloproteinase-3 expression in nucleus pulposus cells requires cooperative signaling via syndecan 4 and mitogen-activated protein kinase-NF-κB axis: Implications in inflammatory disc disease
  9. Role of cytokines in intervertebral disc degeneration: Pain and disc content
  10. Extracellular osmolarity regulates matrix homeostasis in the intervertebral disc and articular cartilage: Evolving role of TonEBP
  11. Xylosyltransferase-1 expression is refractory to inhibition by the inflammatory cytokines tumor necrosis factor α and IL-1β in nucleus pulposus cells: Novel regulation by AP-1, Sp1, and Sp3
  12. An organ culture system to model early degenerative changes of the intervertebral disc II: Profiling global gene expression changes
  13. Molecular regulation of CCN2 in the intervertebral disc: Lessons learned from other connective tissues
  14. Inflammatory cytokines induce NOTCH signaling in nucleus pulposus cells: Implications in intervertebral disc degeneration
  15. Inflammatory cytokines associated with degenerative disc disease control aggrecanase-1 (ADAMTS-4) expression in nucleus pulposus cells through MAPK and NF-κB
  16. Hypoxia-inducible factor (HIF)-1α and CCN2 form a regulatory circuit in hypoxic nucleus pulposus cells: CCN2 suppresses HIF-1α level and transcriptional activity
  17. Tumor necrosis factor α- And interleukin-1β-dependent induction of CCL3 expression by nucleus pulposus cells promotes macrophage migration through CCR1
  18. eNOS transfection of adipose-derived stem cells yields bioactive nitric oxide production and improved results in vascular tissue engineering
  19. Prolyl hydroxylase 3 (PHD3) modulates catabolic effects of tumor necrosis factor-α (TNF-α) on cells of the nucleus pulposus through co-activation of nuclear factor κB (NF-κB)/p65 signaling
  20. Covalent attachment of P15 peptide to titanium surfaces enhances cell attachment, spreading, and osteogenic gene expression
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