Thomas Jefferson UniversityJefferson Medical College

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Eleni Anni

Eleni Anni, PhD
Eleni Anni, PhD

Dr. Anni investigates the reprogramming of key regulatory transcriptional networks by ethanol at the onset of embryonic development in Fetal Alcohol Spectrum Disorder (FASD) using a mouse embryonic stem cell model and an integrated experimental and computational approach encompassing single-cell multiplex flow cytometry, RT-qPCR, microfluidic chips, immunocytochemistry, immunoblotting, mechanistic perturbations and bioinformatic analysis. I have a broad background in ethanol-mediated injury, with experience in key research areas to successfully carry out the proposed work. As a postdoctoral fellow at the University of Pennsylvania, I was trained in several biophysical and biochemical techniques (fluorescence and Raman spectroscopy, ESR, NMR, EXAFS, stopped flow). At Thomas Jefferson University, I expanded my skills to mass spectroscopy to identify proteomic biomarkers of alcoholism. As a PI or co-Investigator on several NIH-funded grants, I developed workflows for screening phage-displayed peptides, synthetic antisense oligonucleotides and small molecules as specific enzyme inhibitors in vitro and in vivo. I successfully administered all aspects of projects, including staffing, budget, progress reports, research protections, and produced peer-reviewed publications. I have a record of applying innovative experimental approaches in projects focusing in ethanol-mediated injury. My laboratory has been offering training in these areas to undergraduate, graduate students and postdoctoral fellows.