Thomas Jefferson UniversityJefferson Medical College

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Overview

We are interested in relating molecular events to their physiological significance. To this end, we employ current system-wide, high throughput data acquisition approaches along with computational analysis. We use genome-scale data sets to construct computational system models of regulatory networks in mammalian cells. The following is a synopsis of current projects in the institute. These projects comprise experimental, computational and informatics domains to varying extents.

We integrate system-wide information from different data sources including gene and microRNA expression, transcription factor activity, genome-wide location analysis, cytokine profiles, and single cell data sets, to develop computational models of intracellular regulatory networks, cell-cell interactions, and organ physiology. We also develop new analysis methods that provide novel insights into the underlying control principles and regulatory mechanisms of physiological behavior.

  • Central autonomic regulatory networks driving the development and maintenance of hypertension
  • Liver function, repair and regeneration altered by adaptation to alcohol consumption
  • Genomic studies of toxicological insult and brain development
  • Effects of alcohol on brain systems involved with addictive and withdrawal processes
  • Intracellular processes induced by growth factor signaling