We are interested in relating molecular events to their physiological significance. To this end, we employ current system-wide, high throughput data acquisition approaches along with computational analysis. We use genome-scale data sets to construct computational system models of regulatory networks in mammalian cells. The following is a synopsis of current projects in the institute. These projects comprise experimental, computational and informatics domains to varying extents.
We integrate system-wide information from different data sources including gene and microRNA expression, transcription factor activity, genome-wide location analysis, cytokine profiles, and single cell data sets, to develop computational models of intracellular regulatory networks, cell-cell interactions, and organ physiology. We also develop new analysis methods that provide novel insights into the underlying control principles and regulatory mechanisms of physiological behavior.
- Central autonomic regulatory networks driving the development and maintenance of hypertension
- Liver function, repair and regeneration altered by adaptation to alcohol consumption
- Genomic studies of toxicological insult and brain development
- Effects of alcohol on brain systems involved with addictive and withdrawal processes
- Intracellular processes induced by growth factor signaling
Daniel Baugh Institute
- Pattern analysis uncovers a chronic ethanol-induced disruption of the switchlike dynamics of C/EBP-β and C/EBP-α genome-wide binding during liver regeneration
- Single-cell transcriptional analysis reveals novel neuronal phenotypes and interaction networks involved in the central circadian clock
- Systemic leukotriene B
4receptor antagonism lowers arterial blood pressure and improves autonomic function in the spontaneously hypertensive rat
- Computational Modeling of Spatiotemporal Ca2+ Signal Propagation Along Hepatocyte Cords
- Integrated live imaging and molecular profiling of embryoid bodies reveals a synchronized progression of early differentiation