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Anatoly Kiyatkin, PhD

Contact Dr. Kiyatkin

1020 Locust Street
Jefferson Alumni Hall, Suite 269
Philadelphia, PA 19107

(215) 503-4794

Medical School

PhD, Moscow Institute of Physics and Technology, Biophysics - 1986

University Appointment

Research Assistant Professor

Research and Clinical Interests

Research interests are focused on the experimental and computational analyses of growth factor and hormone receptor signaling networks. We apply a cross-disciplinary approach that combines experimental studies, nonlinear systems analysis and interactive computational models to achieve a qualitative understanding of integrated signaling responses in normal and malignant cells. Currently our projects encompass: studies of the crosstalk between epidermal growth factor and prolactin-mediated signaling in breast cancer cells; molecular mechanisms and components controlling an alternative MEK-independent route of ERK activation in ER-positive breast cancer cells and the effects of ethanol on this compensatory circuit; system-level research of deregulated invasion and metastasis of squamous carcinoma cells. Through a combination of network analysis, mathematical modeling and experimentation, we plan to identify key switches that promote carcinogenesis and develop novel strategies to effectively treat human cancers with molecular therapeutics.