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Mark L. Tykocinski, MD

Contact Dr. Tykocinski

1025 Walnut Street
College Room 100
Philadelphia, PA 19107

(215) 955-1628

Most Recent Peer-reviewed Publications

  1. Cell Membrane Biology and Juxtacrine Signal Conversion
  2. Fn14•Trail Effectively Inhibits Hepatocellular Carcinoma Growth
  3. Signal Converter Proteins
  4. Energy transfer in "parasitic" cancer metabolism: Mitochondria are the powerhouse and Achilles' heel of tumor cells
  5. Inhibition of effector function but not T cell activation and increase in FoxP3 expression in T cells differentiated in the presence of PP14.
  6. CD40·FasL and CTLA-4·FasL fusion proteins induce apoptosis in malignant cell lines by dual signaling
  7. Inhibition of effector function but not T cell activation and increase in FoxP3 expression in T cells differentiated in the presence of PP14
  8. Fn14-TRAIL, a chimeric intercellular signal exchanger, attenuates experimental autoimmune encephalomyelitis
  9. CTLA-4·Ig converts naive CD4+ CD25- T cells into CD4+CD25+ regulatory T cells
  10. Smad3 and NFAT cooperate to induce Foxp3 expression through its enhancer
  11. CTLA-4·FasL induces early apoptosis of activated T cells by interfering with anti-apoptotic signals
  12. OX40 gene expression is up-regulated by chromatin remodeling in its promoter region containing Sp1/Sp3, YY1, and NF-κB binding sites
  13. CD40·FasL inhibits human T cells: Evidence for an auto-inhibitory loop-back mechanism
  14. α2,6-Sialylation promotes binding of placental protein 14 via its Ca2+-dependent lectin activity: Insights into differential effects on CD45RO and CD45RA T cells
  15. CTLA-4·FasL inhibits allogeneic responses in vivo
  16. Pathology as the enabler of human research
  17. Pregnancy zone protein is a carrier and modulator of placental protein-14 in T-cell growth and cytokine production
  18. Differential regulation of Th1/Th2 cytokine responses by placental protein 14
  19. New designs for cancer vaccine and artificial veto cells: An emerging palette of protein paints
  20. CTLA-4 · FasL induces alloantigen-specific hyporesponsiveness