Rajanikanth Vadigepalli, PhD
Jefferson Alumni Hall, Suite 314C
Philadelphia, PA 19107
(215) 503-2636 fax
Most Recent Peer-reviewed Publications
- Pattern analysis uncovers a chronic ethanol-induced disruption of the switchlike dynamics of C/EBP-β and C/EBP-α genome-wide binding during liver regeneration
- Single-cell transcriptional analysis reveals novel neuronal phenotypes and interaction networks involved in the central circadian clock
- Systemic leukotriene B
4receptor antagonism lowers arterial blood pressure and improves autonomic function in the spontaneously hypertensive rat
- Computational Modeling of Spatiotemporal Ca2+ Signal Propagation Along Hepatocyte Cords
- Integrated live imaging and molecular profiling of embryoid bodies reveals a synchronized progression of early differentiation
PhD, University of Delaware, Chemical Engineering - 2001
BTech, Indian Institute of Technology Madras, Chemical Engineering - 1996
Research and Clinical Interests
We are interested in understanding the operational principles of mammalian tissue plasticity, renewal, repair and regeneration. A key goal is to develop novel clinical interventions and decision-support systems for regenerative medicine. Our transdisciplinary systems biology strategy integrates computational modeling, systems engineering, bioinformatics, functional genomics, high-dimensional data analysis, and single cell scale experimentation. Ongoing collaborative projects focus on liver repair and regeneration, alcoholic liver disease, brainstem neuroinflammation and neuroimmune processes leading to hypertension, cell fate regulation underlying developmental defects, and network modeling of renewal and regeneration in multiple mammalian tissues.
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