Rajanikanth Vadigepalli, PhD
Jefferson Alumni Hall, Suite 314C
Philadelphia, PA 19107
(215) 503-2636 fax
Most Recent Peer-reviewed Publications
- Integrated live imaging and molecular profiling of embryoid bodies reveals a synchronized progression of early differentiation
- A novel comparative pattern analysis approach identifies chronic alcohol mediated dysregulation of transcriptomic dynamics during liver regeneration
- A novel comparative pattern count analysis reveals a chronic ethanol-induced dynamic shift in immediate early NF-κB genome-wide promoter binding during liver regeneration
- Erratum: Molecular variability elicits a tunable switch with discrete neuromodulatory response phenotypes (J Comput Neurosci, DOI 10.1007/s10827-015-0584-2)
- Molecular variability elicits a tunable switch with discrete neuromodulatory response phenotypes
PhD, University of Delaware, Chemical Engineering - 2001
BTech, Indian Institute of Technology Madras, Chemical Engineering - 1996
Research and Clinical Interests
We are interested in understanding the operational principles of mammalian tissue plasticity, renewal, repair and regeneration. A key goal is to develop novel clinical interventions and decision-support systems for regenerative medicine. Our transdisciplinary systems biology strategy integrates computational modeling, systems engineering, bioinformatics, functional genomics, high-dimensional data analysis, and single cell scale experimentation. Ongoing collaborative projects focus on liver repair and regeneration, alcoholic liver disease, brainstem neuroinflammation and neuroimmune processes leading to hypertension, cell fate regulation underlying developmental defects, and network modeling of renewal and regeneration in multiple mammalian tissues.
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