Xugang Xia

Xu-Gang Xia, MD, PhD

Contact Dr. Xia

1020 Locust Street
Jefferson Alumni Hall
Room 336
Philadelphia, PA 19107

(215) 503-9152

Most Recent Peer-reviewed Publications

  1. Increased Ubqln2 expression causes neuron death in transgenic rats
  2. Survival and cause of death among a cohort of confirmed amyotrophic lateral sclerosis cases
  3. Pathogenic Ubqln2 gains toxic properties to induce neuron death
  4. Profiling the genes affected by pathogenic TDP-43 in astrocytes
  5. Cytosolic PINK1 escapes from mitochondria to promote dendritic outgrowth
  6. Expression of ALS-linked TDP-43 mutant in astrocytes causes non-cell-autonomous motor neuron death in rats
  7. Reactive astrocytes secrete lcn2 to promote neuron death
  8. Entorhinal cortical neurons are the primary targets of FUS mislocalization and ubiquitin aggregation in FUS transgenic rats
  9. Mutant TDP-43 in motor neurons promotes the onset and progression of ALS in rats
  10. Early exposure to paraquat sensitizes dopaminergic neurons to subsequent silencing of PINK1 gene expression in mice
  11. Temporal expression of mutant LRRK2 in adult rats impairs dopamine reuptake
  12. TDP-43 potentiates alpha-synuclein toxicity to dopaminergic neurons in transgenic mice
  13. FUS transgenic rats develop the phenotypes of amyotrophic lateral sclerosis and frontotemporal lobar degeneration
  14. Transgenic rat model of neurodegeneration caused by mutation in the TDP gene
  15. Nerve injection of viral vectors efficiently transfers transgenes into motor neurons and delivers RNAi therapy against ALS
  16. Developing tTA transgenic rats for inducible and reversible gene expression
  17. A tightly regulated Pol III promoter for synthesis of miRNA genes in tandem
  18. A construct with fluorescent indicators for conditional expression of miRNA
  19. Therapeutic gene silencing delivered by a chemically modified small interfering RNA against mutant SOD1 slows amyotrophic lateral sclerosis progression
  20. Allele-specific RNAi selectively silences mutant SOD1 and achieves significant therapeutic benefit in vivo