Manuel L. Covarrubias, MD, PhD
Philadelphia, PA 19107
Most Recent Peer-reviewed Publications
- Azi-isoflurane, a photolabel analog of the commonly used inhaled general anesthetic isoflurane
- Inhalational anaesthetics and n-alcohols share a site of action in the neuronal Shaw2 K v channel: Research paper
- A novel N-terminal motif of dipeptidyl peptidase-like proteins produces rapid inactivation of KV4.2 channels by a pore-blocking mechanism
- Kv4 channels underlie the subthreshold-operating A-type K+-current in nociceptive dorsal root ganglion neurons
- The dipeptidyl-peptidase-like protein DPP6 determines the unitary conductance of neuronal Kv4.2 channels
MD, National University of Mexico - 1978
PhD, National University of Mexico, Chemistry - 1980
Max-Planck-Institut fuer Ernaehrungsphysiologie, Dortmund, Germany
Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO
Department of Anatomy and Neurobiology, Washington University School of Medicine, St. Louis, MO
Research & Expertise
Voltage-gated potassium channels; molecular mechanisms underlying function, regulation and interactions with drugs.
The research in my laboratory focuses on voltage-gated potassium channels expressed in brain and heart. We investigate the molecular mechanisms governing the function and regulation of these ion channels. These studies can impact our understanding of neuronal plasticity, epilepsy, chronic pain, arrhythmias, anesthesia and alcohol intoxication. Furthermore, they may unveil potential drug-targets. The research platform of our work is based on a modern multidisciplinary approach, which applies electrophysiology, molecular biology, biochemistry, pharmacology and mathematical modeling.
PEER REVIEW EXPERTISE (1991- )
Physiological Sciences Study Section (NIH). 1995-1996.
MBPP (Membrane Biology & Protein Processing) Study Section (NIH). Regular member from 2005 - 2008.
National Science Foundation. Ad hoc reviewer, 1995, 2008.
Medical Research Council, UK. Ad hoc reviewer, 2007.
Manuscript Reviewer (since 1991): J. Biol. Chem.; J. Gen. Physiol.; Biophys. J.; J. Physiol. (London); Am. J. Physiol. (Cell Physiol.); FEBS Lett.; Proc. Nat. Acad. Sci. USA; J. Neurosci.; Mol. Cell Neurosci; Nature Chem. Biol.
TEACHING EXPERTISE (1992- )
Faculty member of the PhD programs in Cell and Developmental Biology, Molecular Physiology and Biophysics, and Neuroscience at Thomas Jefferson University.
Molecular Approaches to Ion Channel Structure and Function: a Laboratory Course. (sponsored by the Howard Hughes Medical Institute). April 20-May 2, 1997. CINVESTAV, Mexico City.
Graduate Courses: Advanced Cell Biology (CB611); Introduction to Neuroscience (NS700); Molecular and Cellular Neuroscience (NS715); Applications of Statistics in Neuroscience (NS740); Molecular Pharmacology (PR680); Foundations in Biomedical Sciences (GC550); Neurosurgery Board Review: Neuroanatomy and Neurophysiology.
Medical School Courses: Neuroscience (MCBM, ID150).
Course Director of CB611 (Advanced Topics in Molecular Cell Biology). 2004-2010
Course Co-director (Cell Signaling). 2011-
Chair of the Curriculum Committee, The Neuroscience PhD Program, Thomas Jefferson University.
FORMER AND CURRENT GRADUATE STUDENTS AND POSTDOCTORAL FELLOWS
Tapan B. Vyas (1992-1995); Laura Escobar (1994-1995); Henry H. Jerng (1993-1998); Mohammad Shahidullah (1997-2003); Edward J. Beck (1997-2001); Maria T. Pacheco-Cano (1998-1999); Ricardo Hernandez-Pineda (1999-2000); Carmen A. Rocha (2001-2003); Benjamin Kaplan (2002-2004); Thanawath Harris (2002-2008 ); Guangyu Wang (2003-2007); Kevin Dougherty (2004-2008); Jose A. De Santiago-Castillo (2006-2008); Jeffrey Fineberg (2009- ); Annika Fitzpatrick (2009- ); David Ritter (2009- ).
potassium channel; voltage-gated potassium channel; K channel; Kv4 potassium channel; KChIP; DPP6; somatodendritic potassium channels; alkanol; anesthetic; channel inactivation; neuronal channel; cardiac channel; electrophysiology; patch-clamp