Thomas Jefferson UniversitySidney Kimmel Medical College

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Research

The research projects cover different levels of organization, ranging from the investigation of subcellular events to whole organ physiology. Specific areas of research conducted within the department and by graduate program faculty include: energetics and regulation of smooth muscle contraction; ultrastructural analysis of proteins; regulation of cross-bridge function in smooth and cardiac muscle; cardiovascular physiology; cardiovascular gene therapy; physiology of the endothelium; thrombosis and hemostasis; the role of endothelial cells in innate immunity; the pathophysiology of neutrophils and other leukocytes; neutrophil-endothelium interactions; the role of integrins in the regulation of cell differentiation; changes in G protein-coupled receptor signaling in hypertension; signal transduction mediated by protein phosphorylation; diabetes; structure-function studies of voltage-gated ion channels; molecular regulation of the function of cloned voltage-sensitive potassium channels; molecular genetic basis of ion channel diseases; skeletal muscle voltage-gated chloride channels; voltage-gated calcium channels and regulation of calcium channels by second messengers.