Nicole Simone, MD
111 South 11th Street
Philadelphia, PA 19107
Most Recent Peer-reviewed Publications
- MicroRNA alterations driving acute and late stages of radiation-induced fibrosis in a murine skin model
- MicroRNA expression altered by diet: Can food be medicinal?
- The metastatic potential of triple-negative breast cancer is decreased via caloric restriction-mediated reduction of the miR-17~92 cluster
- CD44 is prognostic for overall survival in the NCI randomized trial on breast conservation with 25 year follow-up
- MicroRNAs: The short link between cancer and RT-induced DNA damage response
UMDNJ - New Jersey Medical School - 2003
National Cancer Institute
Thomas Jefferson University Hospital
Methodist Hospital Division of Thomas Jefferson University Hospital
Research and Clinical Interests
I am a board-certified radiation oncologist who has a particular interest in using technological advances in radiation oncology to minimize side effects of treatment while still optimally treating the area of disease. I treat a variety of malignancies but have concentrated on breast cancer for which I have conducted several clinical trials. I work closely with our multidisciplinary team of radiologists, pathologists, surgeons and medical oncologists to ensure that optimal treatment is chosen for each individual patient.
When I'm in the laboratory, I study the effect of combining a healthy diet with standard therapies to try and optimize cancer outcomes. I incorporate the knowledge gained in the laboratory into patient care when appropriate. I also participate in institutional and national clinical trials to help bring state-of-the-art cancer care to my patients. In particular, I have studied the long term toxicity associated with radiation in breast cancer and am currently studying novel methods to treat patients to protect their heart and lungs.
In the laboratory my team and I focus on how caloric restriction, or a reduction in overall calories can augment the response of radiation in hormonally responsive cancers such as breast and prostate cancer. We have shown that caloric restriction, combined with radiation, inhibits both tumor growth and metastases in two aggressive models of breast cancer and are also looking at advanced prostate cancer.