6E74 Bray, Paul F. - Thomas Jefferson University
Thomas Jefferson University
Sidney Kimmel Medical College
Department of Medicine

Bray, Paul F.

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Paul F. Bray, MD

Contact Dr. Bray

1020 Locust Street
Suite 394
Philadelphia, PA 19107

(215) 955-8544
(215) 955-9170 fax

Research & Clinical Interests

Dr. Bray's laboratory studies the role of platelets in cardiovascular disease, and disorders of bleeding and excessive blood clotting. His major areas of investigation include: (1) The role of platelets in arterial thrombosis, with the identification and functional characterization of platelet risk factors and their impact on cardiovascular therapy. He studies how genetic variations in platelet adhesive molecules affect both the clinical and platelet phenotypes. (2) Identification of novel genes and gene products involved in platelet reactivity using genome scan and platelet RNA expression array approaches. (3) Studies on gender differences and hormonal effects on platelet function and thrombosis. (4) Pharmacogenetic studies: a) testing for interactions between candidate genes and hormone therapy using DNA samples from the participants in the Women's Health Initiative, and b) candidate gene and genome-wide scan approaches for determining genes that regulate the platelet response to aspirin.

Publications

Most Recent Peer-Reviewed Publications

  1. Genome-wide association study of platelet aggregation in African Americans
  2. Common variants in the human platelet PAR4 thrombin receptor alter platelet function and differ by race
  3. MicroRNA expression differences in human hematopoietic cell lineages enable regulated transgene expression
  4. Human platelet microRNA-mRNA networks associated with age and gender revealed by integrated plateletomics
  5. The human platelet: Strong transcriptome correlations among individuals associate weakly with the platelet proteome
  6. PDK1 selectively phosphorylates Thr(308) on Akt and contributes to human platelet functional responses
  7. Racial differences in human platelet PAR4 reactivity reflect expression of PCTP and miR-376c
  8. Dengue platelets meet sir arthur conan doyle
  9. Platelet Genomics
  10. Erosive Arthritis and Hepatic Granuloma Formation Induced by Peptidoglycan Polysaccharide in Rats Is Aggravated by Prasugrel Treatment
  11. MicroRNAs in platelet production and activation
  12. The complex transcriptional landscape of the anucleate human platelet
  13. Small RNAs as potential platelet therapeutics
  14. Fractalkine is expressed in early and advanced atherosclerotic lesions and supports monocyte recruitment via CX3CR1
  15. Human genome-wide association and mouse knockout approaches identify platelet supervillin as an inhibitor of thrombus formation under shear stress
  16. Human genome-wide association and mouse knockout approaches identify platelet supervillin as an inhibitor of thrombus formation under shear stress
  17. Platelet biology and response to antiplatelet therapy in women: Implications for the development and use of antiplatelet pharmacotherapies for cardiovascular disease
  18. Identification of a specific intronic PEAR1 gene variant associated with greater platelet aggregability and protein expression
  19. Transfection of human platelets with short interfering RNA
  20. MicroRNAs in platelet production and activation
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