6CC9 McKenzie, Steven E. - Thomas Jefferson University
Thomas Jefferson University
Sidney Kimmel Medical College
Department of Medicine

McKenzie, Steven E.

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Steven E. McKenzie, MD, PhD

Contact Dr. McKenzie

1020 Locust Street
Suite 394
Philadelphia, PA 19107

(215) 955-3900
(215) 923-3836 fax

Research & Clinical Interests

Dr. McKenzie directs two major research projects. The first project involves vascular biology, with a focus on immune-mediated thrombocytopenia and thrombosis syndromes. This work, done in collaboration with Dr. Michael Reilly, led to the first model of heparin-induced thrombocytopenia and thrombosis. New work on effects of elevated cholesterol and athrosclerosis on HITT, and on microparticles and tissue factor, is ongoing.

Publications

Most Recent Peer-Reviewed Publications

  1. Analysis of 13 cell types reveals evidence for the expression of numerous novel primate- And tissue-specific microRNAs
  2. Platelet 12-LOX is essential for FcγRIIa-mediated platelet activation
  3. MicroRNA expression differences in human hematopoietic cell lineages enable regulated transgene expression
  4. Human platelet microRNA-mRNA networks associated with age and gender revealed by integrated plateletomics
  5. The human platelet: Strong transcriptome correlations among individuals associate weakly with the platelet proteome
  6. Identification of a developmental gene expression signature, including hox genes, for the normal human colonic crypt stem cell niche: Overexpression of the signature parallels stem cell overpopulation during colon tumorigenesis
  7. CalDAG-GEFI deficiency protects mice from FcγRIIa-mediated thrombotic thrombocytopenia induced by CD40L and β2GPI immune complexes
  8. Advances in the pathophysiology and treatment of heparin-induced thrombocytopenia
  9. Tyrosine phosphorylation on spleen tyrosine kinase (Syk) is differentially regulated in human and murine platelets by protein kinase C isoforms
  10. MicroRNAs in platelet production and activation
  11. Cooperative integrin/ITAM signaling in platelets enhances thrombus formation in vitro and in vivo
  12. The complex transcriptional landscape of the anucleate human platelet
  13. Monocytes in HIT: An evolving story
  14. CalDAG-GEFI deficiency protects mice in a novel model of FcγRIIA-mediated thrombosis and thrombocytopenia
  15. Safety and pharmacokinetics of subcutaneously administered recombinant activated factor VII (rFVIIa)
  16. PRT-060318, a novel Syk inhibitor, prevents heparin-induced thrombocytopenia and thrombosis in a transgenic mouse model
  17. Amelioration of murine immune thrombocytopenia by CD44 antibodies: A potential therapy for ITP?
  18. Dominant expression of the inhibitory FcγRIIB prevents antigen presentation by murine plasmacytoid dendritic cells
  19. The clot thickens (or not)
  20. Thrombopoietin following transfusion of platelets in preterm neonates
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