Thomas Jefferson University
Sidney Kimmel Medical College
Department of Medicine

Research Activity

The research arm of the Division of Pulmonary & Critical Care is the Jane and Leonard Korman Lung Center at Jefferson.  The focus includes lung cancer as well as benign diseases, such as asthma, sarcoidosis and pulmonary fibrosis, with special emphasis on lung biology.

Several key entities will interact closely and collaboratively to advance our understanding of lung disease and provide a platform for education of our trainees and improve patient care:

Scholarship and research covers a broad spectrum, including:

  • Sponsored clinical trials (typically multi-center pharma trials with strict study design with random allocation)

  • Quality assurance initiatives geared to monitoring, education and improving compliance of accepted practice

  • Investigator-initiated data collection of a particular disease cohort or intervention

  • Establishing registries for data or biobanks for future studies

  • Correlative or translational studies involving human specimens to gain proof-of-concept insights into disease mechanisms

  • Formal controlled laboratory models with experimental design involving mouse models, in-vitro studies, etc.

All of these activities are currently occurring in the Pulmonary & Critical Care Division at Thomas Jefferson University and Thomas Jefferson University Hospitals.  Clinicians, clinical scientists and laboratory scientists are equally engaged and valued. This represents an outstanding environment for growth of a fellow-in-training or academic faculty.

Clinical Trials & Projects

Clinical research is considered to be vital for the mission of an academic division and typically faculty gravitate to academic centers to participate in scholarship, discovery and innovation. A healthy training environment which includes knowledge creation is an integral part of Pulmonary & Critical Care Medicine Fellowship training as mandated by the Accreditation Committee on Graduate Medical Education and the division. Participation in an active research program is an essential component for fellows enrolled in subspecialty fellowship training programs. As such, our program provides an opportunity for fellows to participate in research and other scholarly activities. The program strives to ensure a meaningful, supervised research experience with appropriate protected time. Fellows learn the standards of ethical conduct of research, design and interpretation of research studies, responsible use of informed consent, research methodology, methods of choosing and performing statistical analysis, and interpretation of data.

The division’s scholarly activities are complemented by support and expertise from:

  1. Jefferson Coordinating Center for Clinical Research (JCCCR)
  2. Center for Translational Medicine (CTM)
  3. Graduate Studies Programs

Sponsored Clinical Trials

  • Recombinant human angiotensin converting enzyme Type II (rhACE-2) in ARDS. (PI: Bharat Awsare, MD) (Phase II trial, sponsor is GSK).
  • A Post-marketing Observational Study to Assess Respiratory Tract Adverse Events in Pulmonary Arterial Hypertension Patients Treated with Tyvaso® (Treprostinil) Inhalation Solution. ASPIRE, (PI: Michael Scharf, MD)

  • A 16-Week, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Reslizumab (3.0 mg/kg) Treatment in Patients With Moderate to Severe Asthma. Cephalan (PI: Mani S. Kavuru, MD)

  • Evaluating the Use of Polymyxin B Hemoperfusion in a Randomized Controlled Trial of Adults Treated for Endotoxemia and Septic Shock. EUPHRATES. (PI: Michael Baram, MD)

  • A Multicenter, Double-Blind, Placebo-Controlled Phase 3 Study to Demonstrate the Efficacy and Safety of ACT-293987 in Patients with Pulmonary Arterial Hypertension. Griphon (PI: Michael Scharf, MD)

  • Registry to Prospectively Describe Use of Epoprostenol for Injection ("RTS Epoprostenol") in Patients with Pulmonary Arterial Hypertension *No Longer Enrolling New Patients. PROSPECT (PI: Michael Scharf, MD)

  • COPD Study with a LABA/IC (BI). (PI: William Sexauer, MD)

  • A Phase 2, Randomized, Double-Blind, Placebo-Controlled, Multi-Center Study to Assess the Efficacy and Safety of GS-6624 (LOXL2) in Subjects with Idiopathic Pulmonary Fibrosis (RAINIER, Gilead Sciences Inc)(PI: Ross Summer, MD, CoI Drs Kavuru & Weibel)

Quality Assurance/Education Projects

  • Severe sepsis pathway (ED/MICU/Infectious Diseases) with (Drs. Awsare, Flomenberg, and Lopez)

  • Severe sepsis hospital rollout (collaboration with heme/malignancy/onlcology) (Drs. Awsare & Flomenberg)

  • GI bleed pathway (GI/Interventional Radiology) with (Drs. Awsare, Mitchell Conn, and David Eschelman)

  • ABCDE protocol (collaboration with nursing, respiratory therapy, physical therapy, anesthesia/pain service, surgery); MICU initiative

  • Development & Implementation of a multi-disciplinary COPD exacerbation in-patient pathway (Drs. Gaurav Kumar, Vaid, Sexauer, Kavuru)

  • A quality improvement project for documentation of family meetings in the medical ICU: (PI: Urvashi. Vaid, MD with fellow Geoffrey Koff, MD and Co-PI: David Oxman, MD)

  • How to teach (3 minute fellow lectures) (Drs Baram & Mangione)

Fellow/Faculty Research-in-Progress Clinical Projects

  • Utility of Rockall score in outcomes in lower GI bleeding (PI: David Manoff, MD & Dr Awsare)

  • Incidence of hyperglycemia in septic shock patients receiving steroids for adrenal insufficiency (PI: Lindsay McCann & Dr. Vaid)

  • Utility of oxygenation index as predictor of failure of conventional ventilation and mortality (PI: Vanjul Agarwal, MD and Roselle Almeida, MD & Drs Baram & Vaid)

  • Code status change following an RRT in an academic medical center: An observational study of patient characteristics and outcomes. (PI: Michael Baram, MD and Co PI: Urvashi Vaid, MD and David Oxman, MD)

  • PAH due to Hep B, C without portal hypertension. Need to define portal hypertension. Do we bring in liver specialists? (PI: Michael L. Scharf, MD)

  • Role of tissue Doppler imaging in assessing RV function prior to/in absence of elevated estimated PA pressures in various chronically at risk populations. Safety of performing ISWT in PAH population Scleroderma? (PI: Michael L. Scharf, MD)

  • Compare 6MWD, ISWT, VO2max in various chronically at risk populations. (PI: Michael L. Scharf, MD)

  • What constitutes and meaningful improvement in ISWT distance? Questionnaire, Functional Class, Pre- and post-therapy CTA imaging of RV size and function (PA caliber) in various chronically at risk populations. (PI: Dr Michael Scharf, with Misha Peter, MD and Dinesh Sharma, MD)

  • Outcomes of percutaneous tracheostomy in the medical ICU: retrospective review (Drs Restrepo & Baram)

  • Utilization of ECMO in the ICU: optimal timing, role of biomarkers, comparison to a national database, etc. (Drs. Kumar Gaurav, Mike Baram, Nick Cavarocchi)

  • Impact of computerized order entry alert on the optimal use of ARDSnet ventilator settings (Drs. Sid Bagga & Michael Baram)

  • Outcome of patients with solitary pulmonary nodules: retrospective chart review (Drs. Vanjul Agarwal, Rohit Kumar, Boyd Hehn, Mani Kavuru)

Miscellaneous Clinical Projects Involving Other Disciplines

  • IRB approved for recruitment of patient surrogates to form part of advisory board for PCORI grant application for a new tool "GO-CARE" to assess outcomes and patient/family satisfaction with meetings in the ICU. (PI: Susan Parks, MD Co-PI: Urvashi Vaid, MD and David Oxman, MD)

  • COPD management: medical home in primary care versus subspecialty care (PCORI grant submission) (PI: Lawrence Ward, with Co-Is Drs Rhea Powell, Kavuru, Sexauer)

Recent Publications

2013-2014

Sidharth Bagga, Dalton E. Paluzzi, Christine Y. Chen, Jeffrey M. Riggio, Paul E. Marik, Michael Baram.  “Better Ventilator Settings using a computerized clinical decision tool.”  Respiratory Care  Dec 2013  

Shinya Unai, MD, Joseph Miessau, MS, Pawel Karbowski, MS, Michael Baram, MD, Hitoshi Hirose, MD, Nicholas C. Cavarocchi, MD.  “Caution for anabolic androgenic steroid use -a case report of multiple organ dysfunction syndrome.”  Respiratory Care. Dec 2013; 58(12): 159-163.  DOI: 10.4187/respcare.02338  Case report and review of the literature on systemic toxic effects of androgenic steroids. Toxic effects can be so severe to require ecmo support.  

Michael Baram M.D., Anand Kommuri M.D., Subhashini A. Sellers M.D., John R. Cohn, M.D. “ACE Inhibitor-Induced Angioedema”  The Journal of Allergy and Clinical Immunology: In Practice (JACI) Sept 2013; 1(5): 442-445. Review of the literature on ACE Angioedema.  Symptoms, incidence, mechanism, therapeutic options and economics of this common occurrence were reviewed.

Gaurav K, Vaid U, Sexauer W, Kavuru MS.  Hosp Pract (1995). 2014 Apr;42(2):58-69. doi: 10.3810/hp.2014.04.1104. PMID: 24769785.

Christopher R Gilbert, Michael Baram and Nicholas C Cavarocchi. "Smoking wet": respiratory failure related to smoking tainted marijuana cigarettes. Texas Heart Institute journal / from the Texas Heart Institute of St. Luke's Episcopal Hospital, Texas Children's Hospital. 2013; 40 (1) p64-7.

PMCID: PMC3568288  Case series and review of the literature on the toxic effects of additives to marijuana.   Some of these additives can result in severe ARDS requiring ecmo.

Hasan N, Kumar R, Kavuru MS.  Lung cancer screening beyond low-dose computed tomography: the role of novel  biomarkers.  Lung 2014; Published online Aug 10, 2014.

Hasan N and ML Scharf.  Acute Respiratory Distress Syndrome Secondary to Household Use of Chlorine-Based Bleach: Brief Report and Review of the Literature.  Mater Sociomed. 26(3): 211-213, 2014.

Aagaard E, Kane GC, Conforti L, Hood S, Caverzagie KJ, Smith C, Chick D, Holmboe E, Iobst W Feedback on the use of the Internal Medicine Reporting Milestones in Resident Promotion Journal Grad Medical Education 2013 (September) ; Vol. 5: 433-438.

Kane GC.  The Doctor’s Letter of Condolence: An Important part of the Continuum of Care for the Dying Patient.  ADEC: Journal of the Thanatology Association.  October 2013:39:25-26.

Oxman DA, Adams CD, Deluke G, Philbrook L, Ireland P, Mitani A, Panizales C, Frendl G, Rogers SO.

J Pharm Pract. 2014 Mar 19. Improving Antibiotic De-Escalation in Suspected Ventilator-Associated Pneumonia: An Observational Study With a Pharmacist-Driven Intervention.

Williams M, Alban RF, Hardy JP, Oxman DA, Garcia ER, Hevelone N, Frendl G, Rogers SO Jr.

J Crit Care. 2014 Jun;29(3):445-9. In-hospital fellow coverage reduces communication errors in the surgical intensive care unit.

Deshpande DA, Yan H, Kong KC, Tiegs BC, Morgan SJ, Pera T, Panettieri RA, Eckhart A, and Penn RB. Exploiting functional domains of GRK2/3 to alter the competitive balance of pro- and anti- contractile signaling in airway smooth muscle. FASEB J, 2014 Feb; 28 (2):956-965.

Morgan SJ, Deshpande DA, Tiegs BC, Misior AM, Yan H, Hershfeld AV, Rich TC, Panettieri RA, An SS, Penn RB. Beta-agonist-mediated relaxation of airway smooth muscle is PKA-dependent. J Biol Chem. 2014 Jun 27. pii: jbc.M114.557652.

Pera T, Penn RB. Crosstalk between beta-2-adrenoceptor and muscarinic acetylcholine receptors in the airway. Curr Opin Pharmacol. 16:72-81, 2014 PMID:24747364

Penn RB. Far from Dissapointing. Am J Respir Crit Care Med. 189(3):360, 2014 PMID:24484334

Penn RB, Bond RA, Walker JK. GPCRs and arrestins in the airways: implications for asthma. Handb Exp Pharmacol. 219:387-403,2014. PMID:24292841

Deshpande DA, Yan H, Kong KC, Tiegs BC, Morgan SJ, Pera T, Panettieri RA, Eckhart A, and Penn RB. Exploiting functional domains of GRK2/3 to alter the competitive balance of pro- and anti- contractile signaling in airway smooth muscle. FASEB J, 2014 Feb; 28 (2):956-965.

Morgan SJ, Deshpande DA, Tiegs BC, Misior AM, Yan H, Hershfeld AV, Rich TC, Panettieri RA, An SS, Penn RB. Beta-agonist-mediated relaxation of airway smooth muscle is PKA-dependent. J Biol Chem. 2014 Jun 27. pii: jbc.M114.557652.

Fields A, Julien H, Scharf ML, and P Mehotra.  "Right Ventricular Fractional Area Change is Predictive of Elevated Brain Natiuretic Peptide in Patients with Pulmonary Arterial Hypertension". (CHEST 2014 Annual Meeting in Austin, Texas, USA).

Romero, F., Shah, D., Duong, M., Stafstrom, W., Hoek, JB., Kallen, CB., Lang, CH. , Summer, R. Chronic alcohol ingestion in rats alters lung metabolism, promotes lipid accumulation and impairs alveolar macrophage functions.  Am J Respir Cell Mol Biol 2014 Jun 8 [PMID: 24940828].

Ding SY, Lee MJ, Summer R, Liu L, Fried SK, Pilch PF. Pleiotropic Effects of Cavin-1 Deficiency on Lipid Metabolism. J Biol Chem. 2014 Feb 7 [PMID: 24509860].

Shah, D., Romero, F., Stafstrom, W., Duong, M., Summer, R. Extracellular ATP mediates the late phase of neutrophil recruitment to the lung after LPS induced injury. 2014 Jan; 306(2):L152-61 [PMID: 24285266].

Haley, S., Shah, D., Romero, F., Summer, R. “Scleroderma Related Lung Disease: Is there a pathogenic role for adipokines?” Curr Rheumatol Rep. 2013 Dec;15(12):381. [PMID: 24173692].

Vaid U, Singer E, Marhefka G, Kraft Wk, Baram M.  “Poor Positive Predictive Value of McConnell’s Sign on Transthoracic Echocardiography for the Diagnosis of Acute Pulmonary Embolism.”  Hospital Practice. August 2013; 41(3): 23-7.  DOI: 10.3810/hp.2013.08.1065

Retrospective review of McConnell’s sign to assess the positive predictive value of echocardiograms to diagnose PE.  McConnell’s sign was about 50% predictive of a  PE.

Abstracts & Presentations

Agarwal V., Almeida R., Gaurav K., Kommuri A., Hsieh J., Kim J., Vaid U., Baram M., Awsare BK. “Oxygenation Index as a Predictor of Failure of Conventional Ventilation and Mortality in Acute Respiratory Distress Syndrome.”  American Thoracic Society Meeting, Philadelphia, PA, 2013.

Akshay Sanan, Harrison Pitcher, Michael Baram, Hitoshi Hirose, Nicholas C. Cavarocchi

ARDS secondary to Mycoplasma pneumoniae treated with VV-ECMO and Prone Position

Chest. 2014; submitted American College of Chest Physicians (ACCP) 2014: Austin, Texas

Mycoplasma pneumoniae should be considered as an etiologic agent for ARDS and the use of ECMO and RotoProne beds may have a valuable role in the expedited recovery of a patient’s respiratory status.

Courtney Stull, Michael Baram, Harrison Pitcher, Hitoshi Hirose, Kumar Gaurav, Nicholas Cavarocchi.  Predictors of a Successful Wean from Extracorporeal Membrane Oxygenation (ECMO) for ARDS.  Society of Critical Care Medicine (SCCM) 2014: San Francisco, CA.  Critical Care Med. 41(12): p356-374. Dec 2013.

Sooppan R, Cavarocchi N, Pitcher H, Yang Q, Unai S, Baram M, Awsare BK, Hirose H.  “Veno-venous extracorporeal membrane oxygenation (VV-ECMO) as a bridge to complete recovery in influenza type A related refractory ARDS.”  24th Annual ELSO Conference.  Philadelphia, PA, 2013.

Gaurav K., Cavarocchi N., Hitoshi H., Vaid U., Awsare BK, Agarwal V., Almeida R., Toscano A., Baram, M. “We Came, We Saw, We Cannulated!” American Thoracic Society Meeting, Philadelphia, PA, 2013.

Gaurav K, Vaid U, Sexauer W, Kavuru MS. Readmissions after hospital Discharge with Acute Exacerbation of COPD: Are we missing something? Hosp Pract (1995). 2014 Apr;42(2):58-69.

Presented at the annual Sleep meeting in June 2014 as poster presentations

i. Utility of the STOP-BANG Questionnaire for Identifying Obstructive Sleep Apnea in Patients Undergoing Bariatric Surgery Karen Jablonski , MD1, Ritu Grewal , MD, Ramya Punati, Shivam Saxena, Karl Doghramji1, Alec Beekley, MD, David Tichansky , MD.

ii.  Does A Short, Thick Neck Predict Obstructive Sleep Apnea?

Ramya Punati, B.S., Shivam Saxena, B.S., Constantine Daskalakis, Sc.D., Salvatore Mangione, M.D., Karl Doghramji, M.D., Ritu Grewal, M.D.

Hasan N., Kahn D. Awsare BK. “Post-transplant lymphoproliferative disease presenting with fulminant tumor lysis syndrome.” Society of Critical Care Medicine International Meeting, San Juan, Puerto Rico, 2013.

Nagaraja M, Montemuro, P, Jaffe B, Kahn D, Awsare BK.  “An acute cause of hypoxemic respiratory failure in a patient with chronic lymphocytic leukemia.”  Society of Critical Care Medicine.  San Francisco, CA, 2014.

Koff GL, Montemurro P, Nagaraja M, Oxman DA, Vaid U. The Quality Of Death And Dying: A Retrospective Analysis Of Patient Characteristics And Family Meetings In Patients Dying In A Tertiary Medical Intensive Care Unit. Am J Respir Crit Care Med 189;2014:A1139

Oxman D. An Interdisciplinary Program for Improving the Recognition and The Quality of Death and Dying: A Retrospective Analysis of Patient Characteristics and Family Meeting in Patients Dying in a Medical Intensive Care Unit. ATS Annual Congress, May 2014, Abstract# 1139

Oxman D.  An Interdisciplinary Program to Improve the Treatment of Severe Sepsis. Society of Critical Care Medicine Annual Congress, January 2014 Abstract#1072

Anaplasmosis and ARDS. Society of Critical Care Medicine Annual Congress, January 2014.Abstract # 1231

Oxman D. Oettinger G, Pugliese R, El-Beyrouty C, McDaniel C, Tyron T, Thomas K, Sorokin R, Delisle D, Awsare BK, Portale J, Riggio J, Flomenberg P, for the Thomas Jefferson University Sepsis Working Group. “Developing and Implementing an Interdisciplinary Protocol for Improving the Recognition and Treatment of Emergency Medicine Patients with Sepsis.” Society of Critical Care Medicine.  San Francisco, CA, 2014.

Restrepo R., Madan N., Farber J., Baram M., Awsare BK. “Macrophage Activation Syndrome Associated with Atrial Myxoma.” Society of Critical Care Medicine International Meeting, San Juan, Puerto Rico, 2013.

Shah, D. Romero, F., Stafstrom, W., Duong, M., Summer, R.S.,  Extracellular ATP regulates the late phase of neutrophil recruitment to the lung after LPS induced injury. Obesity and Metabolism: An emerging Frontier in Health and Disease. Conference. Vermont 2013

Shah, D. Romero, F., Stafstrom, W., Duong, M., Summer, R.S., Obesity predisposes to the development of LPS-induced acute lung injury in mice. Obesity and Metabolism: An emerging Frontier in Health and Disease. Conference. Vermont 2013

Ali A, Sutton E, Vaid U. A Case Of Rapidly Progressive Dengue Hemorrhagic Fever And The Use Of Albumin Dialysis With The Molecular Adsorbent Recirculating System. Am J Respir Crit Care Med 189;2014:A6480

Sutton E, Ali A, Vaid U. A Case Of Hemophagocytic Lymphohistiocytosis In The Setting Of Profound HIV Immunosuppression And Cryptococcal Bacteremia. Am J Respir Crit Care Med 189;2014:A6149

Book Chapters

Deshpande D.A. and Wang M. (2014). Mouse model to explore aging lung. In “Understanding Aging Lung”. Edited by Lesaux Jourdan C, Meiners S and Rojas M. Wiley Blackwell publications.

Deshpande D.A. and Liggett S.B. (2013). Regulation of intracellular calcium by bitter taste receptors on airway smooth muscle. In “Calcium Signaling In Airway Smooth Muscle Cells”. Edited by Wang YX. Springer Publications. pp 409-422.

Deshpande D.A., Guedes A, Dileepan M, Walseth T.F., and Kannan M.S. (2013). CD38-cyclic ADP ribose-mediated calcium signaling in airway smooth muscle. In “Calcium Signaling In Airway Smooth Muscle Cells”. Edited by Wang YX.  Springer Publications. pp 247-268.

Member of Study Section or Committee:

Deshpande D.A NIH                 PO1HL081064           May 2014

Deshpande D.A NIH                 PO1AG043355           July 2014

Deshpande D.A National Committee

Deshpande D.A American Thoracic Society- Member, Program committee

Deshpande D.A American Thoracic Society- Member, Planning Committee

Deshpande D.A American Thoracic Society- Member, Aging Research Group

Raymond Penn:  B. Member of NIH standing study section Lung Cell Molecular Immunology (LCMI)

Editorial Boards

M. Baram

  • Influenza and Co-morbidities: Helping to Prevent Disease in Older Patients

topic #1 The Cardiovascular Burden of Influenza

topic #2 Immune Senescence: A Context for Clinical Influenza

  • Austin Journal of Pulmonary and Respiratory Medicine

  • Journal of Emergency Medicine and Surgical Care (EMSC)

R. Penn

  • Journal Editor since June 2013

  • American Journal of Respiratory and Critical Care Medicine 2013

  • American Thoracic Society – Guidelines and Documents - 2014

  • British Journal of Pharmacology – 2013, 2014

  • Circulation - 2013

  • Critical Care Medicine –2013

  • Critical Care – 2013

  • Journal of Allergy – 2013

  • Journal Applied Physiology – 2014

  • Journal American Heart Association JAHA – 2013

  • PlosOne – 2014

  • Managing Editor:  British Journal of Pharmacology, Respiratory Research

  • Editorial Board: AJP Lung, American Journal of Respiratory Cell and Molecular Biology

  • Member of NIH standing study section Lung Cell Molecular Immunology (LCMI)

  • Managing Editor:  British Journal of Pharmacology, Respiratory Research

  • Editorial Board: AJP Lung, American Journal of Respiratory Cell and Molecular Biology

2012-2013

Gilbert CR, Lerner A, Baram M, Awsare BK.  Utility of Flexible Bronchoscopy in the Evaluation of Pulmonary Infiltrates in the Hematopoietic Stem Cell Population—A Single Center Fourteen Year Experience.  Arch Bronconeumol;2013.

Urvashi Vaid, Gregary Marhefka, Esme Singer, Michael Baram. Poor Positive Predictive Value of McConnell’s Sign on Transthoracic Echocardiography for the Diagnosis of Acute Pulmonary Embolism.  Hospital Practice (Accepted 2013) Manuscript ID HP-ST-2013-0002.R1. 

Michael Baram M.D., Anand Kommuri M.D., Subhashini A. Sellers M.D., John R. Cohn, M.D. “ACE Angioedema”  The Journal of Allergy and Clinical Immunology: In Practice (JACI) (Accepted 2013)  INPRACTICE-D-13-00118.

Sidharth Bagga, Dalton E. Paluzzi, Christine Y. Chen, Jeffrey M. Riggio, Paul E. Marik, Michael Baram. Improved compliance to lower initial tidal volume supported via a computerized clinical decision tool.  Respiratory Care (Submitted) Manuscript ID RC-02223.R2

Shinya Unai, MD, Joseph Miessau, MS, Pawel Karbowski, MS, Michael Baram, MD, Hitoshi Hirose, MD, Nicholas C. Cavarocchi, MD.  Caution for anabolic androgenic steroid use -a case report of multiple organ dysfunction syndrome.  Respiratory Care. Accepted April 2013.  Manuscript ID RC-02338.R2 DOI: 10.4187/respcare.02338.

Ricardo Restrepo, Esme F. Singer, Michael Baram. Hepatopulmonary Syndrome and Porto-Pulmonary Hypertension Review.  Hospital Practice. April 2013 DOI: 10.3810/hp.2013.04.1049 https://hospitalpracticemed.com/doi/10.3810/hp.2013.04.1049

Joshua Wong, Vei Shaun Siow, Harrison Pitcher, Matthew V DeCaro, Michael Baram, Hitoshi Hirose, Nicholas C Cavarocchi..  End Organ Recovery and Survival with the QuadroxD Oxygenator in Adults on Extracorporeal Membrane Oxygenation. World Journal of Cardiovascular Surgery (WJCS)- 2012,2,73-80.  DOI: 10.4236/wjcs.2012.24015.

Christopher Gilbert, D.O., Andrew Lerner, M.D., Michael Baram, M.D., Bharat Awsare, M.D. Utility of Flexible Bronchoscopy in the Evaluation of Pulmonary Infiltrates in the Hematopoietic Stem Cell Transplant Population - A Single Center Fourteen Year Experience. Archivos de Bronconeumología.  Feb  2013 DOI: 10.1016/j.arbres.2012.11.012.

Christopher Gilbert, Tajendar Vasu, Michael Baram.  Use of Mechanical Ventilation and Renal Replacement Therapy in Critically Ill Hematopoietic Stem Cell Transplant Recipients.  Biology of Blood and Marrow Transplantation.  April 9, 2013 DOI: 10.1016/j.bbmt.2012.09.010

Christopher R Gilbert, Michael Baram and Nicholas C Cavarocchi. "Smoking wet": respiratory failure related to smoking tainted marijuana cigarettes.   Texas Heart Institute journal / from the Texas Heart Institute of St. Luke's Episcopal Hospital, Texas Children's Hospital. (2013) 1:40

E. Folch, O.Ibrahim, A. Majid. Cardiac Wall Mass Identified by Endobronchial Ultrasonography. Journal of Bronchology and Interventional Pulmonology (approved pending publication).

Hepatopulmonary Syndrome and Porto-Pulmonary Hypertension Review. Esme F. Singer, Michael Baram, Ricardo Restrepo. Accepted For Publication. Hospital Practice. April 2013

Oxman DA , et al: Postoperative antibacterial prophylaxis for the prevention of infectious complications associated with tube thoracostomy in patients undergoing elective general thoracic surgery: a double-blind, placebo-controlled, randomized trial. JAMA Surg. 2013 May;148(5):440-6.  Book Chapter: Community Acquired Pneumonia.  In: Intensive Care Unit Manual, 2nd Edition, Saunders 2013.

Alveolar macrophage cathelicidin deficiency in severe sarcoidosis.  Barna BP, Culver DA, Kanchwala A, Singh RJ, Huizar I, Abraham S, Malur A, Marshall I, Kavuru MS, Thomassen MJ.  J Innate Immun. 2012;4(5-6):569-78. doi: 10.1159/000339149. Epub 2012 Jul 3.PMID:22759465[PubMed - indexed for MEDLINE] Free PMC Article

Rituximab therapy in pulmonary alveolar proteinosis improves alveolar macrophage lipid homeostasis.  Malur A, Kavuru MS, Marshall I, Barna BP, Huizar I, Karnekar R, Thomassen MJ.  Respir Res. 2012 Jun 14;13:46. doi: 10.1186/1465-9921-13-46.

Extracorporeal membrane oxygenation to support whole-lung lavage in pulmonary alveolar proteinosis: salvage of the drowned lungs.  Hasan N, Bagga S, Monteagudo J, Hirose H, Cavarocchi NC, Hehn BT, Kavuru MS.  J Bronchology Interv Pulmonol. 2013 Jan;20(1):41-4. doi: 10.1097/LBR.0b013e31827ccdb5

Govender, P., Romero, F., Shah, D., Paez, J., Ding, SY., Liu, L., Gower, A., Baez, E., Aly, S.S., Pilch, P., Summer, R. Cavin1; a regulator of lung function and macrophage phenotype, PlosOne 2013. [PMID: 23634221].

Li P, Liu Y, Yi B, Wang G, You X, Zhao X, Summer R, Qin Y, Sun J. MicroRNA-638 Is Highly Expressed in Human Vascular Smooth Muscle Cells and Inhibits PDGF-BB Induced Cell Proliferation and Migration Through Targeting Orphan Nuclear Receptor NOR1. Cardiovasc Res. 2013 Apr 3.

Fang F, Liu L, Yang Y, Tamaki Z, Wei J, Marangoni RG, Bhattacharyya S, Summer RS, Ye B, Varga J. The adipokine adiponectin has potent anti-fibrotic effects mediated via adenosine monophosphate-activated protein kinase: novel target for fibrosis therapy. Arthritis Res Ther. 2012 Oct 23;14(5):R229

Walkey AJ, Summer R, Ho V, Alkana P. Acute respiratory distress syndrome: epidemiology and management approaches. Clin Epidemiol. 2012;4:159-69.

Summer, R., Wiener, R., Carroll, D., Sager, A. Physician perception of the impact of productivity measures on academic practice. Arch Intern Med. 2012 Jun 25;172(12):967-

Cavallazzi, R,  Awe OO, Vasu TS, Hirani A, Vaid U, Kraft WK, and Kane GC.  MELD scores for predicting outcome in critically ill patients with liver cirrhosis.   J Critical Care; August 2012, vol 27:4:424(e1-e6).

Salt J, Iobst WF, Kuehl SP,Kane GC. The Clinical Competency Committee: Approaches   to Function, Composition, and Legal Issues.  Academic Internal Medicine  Insight:2012;10(1),22-23.

William Iobst, MD (Chair), Eva Aagaard, MD , Hasan Bazari, MD,  Timothy Brigham, MDiv, PhD , Roger W. Bush, MD, Kelly Caverzagie, MD, Davoren Chick, MD, Michael Green, MD, Kevin Hinchey, MD , Eric Holmboe, MD, Sarah Hood, MS ,Gregory Kane, MD ,Lynne Kirk, MD,

Lauren Meade, MD, Cynthia Smith, MD Susan Swing, PhD (The internal Medicine Milestone Writing Group),  A joint initiative for the ACGME and ABIM.  The Internal Medicine Milestone Project.  2013  published at: http://www.acgme-nas.org/assets/pdf/Milestones/InternalMedicineMilestones.pd also published as supplement:  Journal Grad Medical Education 2013;March;pgs14-23

Caverzagie KJ, Iobst WF, Aagaard EM, Hood S, Chick D, Kane GC, Brigham TP, Swing SR, Meade LM, Bazari H, Bush RW, Kirk LM, Green ML, Hinchey KT, and Smith CD.   The Internal Medicine Reporting Milestones and the Next Accreditation System  Ann Intern Med 2013 (e publication, January 22, 2013)

Abstracts / National Presentations

Hasan, N, Madan N, Kumar R, Awsare BK.  Severe Sepsis with Clostridium Tertium Bacteremia in an Immunocompetent Host. Society of Critical Care Medicine International Meeting, Houston, 2012.

Madan N, Gilbert C, Awsare BK, Baram M, Kommuri, A.  Baclofen Pump Failure Leading to Severe and Prolonged Withdrawal. Society of Critical Care Medicine International Meeting, Houston, 2012.

Kumar V, Bagga S, Leiby B, Awsare BK.  “Survey of ICU Physicians Regarding Components of Daily ICU Goal Sheet.” American College of Chest Physicians’ CHEST 2011 meeting, Honolulu, 2011.

Bagga S., Chen C., Paluzzi D., Nagaraja M., Vipul K., Malloy C., Riggio J., Awsare BK, Baram M.  “Effect of Implementing Expert Rules on Tidal Volumes.” Society of Critical Care Medicine International Meeting, Houston, 2012.

Restrepo R., Madan N., Farber J., Baram M., Awsare BK. “Macrophage Activation Syndrome Associated with Atrial Myxoma.” Society of Critical Care Medicine International Meeting, San Juan, Puerto Rico, 2013.

Hasan N., Kahn D. Awsare BK. “Post-transplant lymphoproliferative disease presenting with fulminant tumor lysis syndrome.” Society of Critical Care Medicine International Meeting, San Juan, Puerto Rico, 2013.

Gaurav K., Cavarocchi N., Hitoshi H., Vaid U., Awsare BK, Agarwal V.,Almeida R., Toscano A., Baram, M. “We Came, We Saw, We Cannulated!” American Thoracic Society Meeting, Philadelphia, PA, 2013.

Agarwal V., Almeida R., Gaurav K., Kommuri A., Hsieh J., Kim J., Vaid U., Baram M., Awsare BK. “Oxygenation Index as a Predictor of Failure of Conventional Ventilation and Mortality in Acute Respiratory Distress Syndrome.” American Thoracic Society Meeting, Philadelphia, PA, 2013.

Cohn JR, McDaniel C, Richards N, Au C, Baram M. Prompt reversal of airway obstruction secondary to angiotensin converting enzyme inhibitor (ACEI) induced angioedema by Ecallantide:  A Case Report. J Allergy Clin Immunol 2012:129: AB 220.  American Academy of Allergy, Asthma, and Immunonology (AAAAI) March 2012

Sid Bagga, M.D., Vipul Kumar, M.D., Christina Chen, Jeff Riggio, M.D., Michael Baram, M.D. Expert rules improved Compliance with ARDS Protocols. American Thoracic Society International Conference in San Francisco, California.  2012 (poster)

Sid Bagga, M.D., Michael Baram, M.D. Treatment of Hyperammoniemia by Craniotomy. American Thoracic Society International Conference in San Francisco, California.  2012 (poster) 

Nikhil Madan, Christopher Gilbert, Bharat Awsare, Michael Baram, Anand Kommuri Baclofen Pump Failure Leading to Severe and Prolonged Withdrawal.  #922 -Supplement Critical Care Medicine Society of Critical Care Medicine (SCCM) 2012:

Cara McDaniel, Michael Baram, Cindy Wordell, John R. Cohn.  Ecallantide treatment for angiotensin converting enzyme inhibitor induced angioedema (ACEI-IA): a case series and pharmacoeconomic assessment:  Critical Care Medicine: Dec. 2011 Vol 39 (12) p 260 Poster 933 Society of Critical Care Medicine (SCCM) 2012:

Anand Kommuri M.D, Rohit Kumar MD, Nikhil Madan M.D, Michael Baram MD.     Unusual Case of Pulmonary Infiltrates in a HIV patient: Pulmonary Talc Granulomatosis.  Society of Critical Care Medicine (SCCM) 2012: Houston Texas

Nikhil Madan M.D, Nicholas Cavarocchi M.D, Hitoshi Hirose M.D, Michael Baram M.D, Christopher Gilbert D.O, Anand Kommuri M.D. (2012,February) Interesting Cause of Hypoxia on Veno-Arterial Extra Corporeal Membrane Oxygenation (ECMO).  Society of Critical Care Medicine (SCCM) 2012: Houston Texas

E. Folch, O.Ibrahim, A. Majid. Cardiac Wall Mass Identified by Endobronchial Ultrasonography. Journal of Bronchology and Interventional Pulmonology (approved pending publication).

Ricardo Restrepo, Michael Baram, Omar Ibrahim, Kumar Vipul. Abstract. Diffuse Alveolar Hemorrhage in a Patient with Hemoglobin SC Disease. Chest. 2012,142. 310A

Ricardo Restrepo, Michael Baram, Paul Marik. Abstract. Blood Transfusion- Who Knows What To Do? A Survey of Medical House-Staff. Chest. 2012,142. 537A

Romero-Vasquez, F., Shah, D., Stafstrom, W., Summer, R.S. Impaired AMP-Activated Protein Kinase (AMPK) Activity And Increased Lipogenesis Are Early Events In The Development Of Bleomycin-Induced Pulmonary Fibrosis A5659, 2013.

Shah, D., Romero-Vasquez, F., Stafstrom, W., Summer, R.S., C1q Deficiency Increases Susceptibility To LPS-Induced Acute Lung Injury. A4798, 2013.

Kirkpatrick, A., Walkey, A.J., Summer, R.S., Delayed Recognition Of Severe Sepsis 2013.A1562.

Ding, S., Jee M.J., Liu, L., Summer R, Fried, S.K., Pilch, P.F. Pleiotropic effects of Cavin-1 deficiency on in vivo and in vitro lipid metabolism. Keystone Symposium.

Baez, E., Aly, S., Ding, S., Govender, P, Pilch, P, Summer R, Boston, MA, Cavin-1 Deficiency Alters Macrophage Number And Phenotype In Lung Am J Respir Crit Care Med p.A6727, 2012.

Case Reports

Daron Kahn, Michael Baram “Crash And Burn: A True Adrenal Crisis” American Thoracic Society (ATS) Philadelphia, PA May 2013,       

Daron Kahn, Geoff Koff,  Michael Baram.  “Using Procalcitonin in ECMO.”  -Supplement Critical Care Medicine 40;2012 supplement 12:1269  Society of Critical Care Medicine (SCCM 42) 2013: