Thomas Jefferson University
Sidney Kimmel Medical College
Department of Medicine

Deshpande, Deepak

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Deepak Deshpande, PhD

Contact Dr. Deshpande

1020 Locust Street
Room 543B
Philadelphia, PA 19107

(215) 955-3305
(215) 503-5731 fax

Education

PhD, College of Veterinary Medicine, University of Minnesota, 2004
MS, Veterinary College, University of Agricultural Sciences, Bangalore, India, 1997
DMV, Veterinary College, University of Agricultural Sciences, Bangalore, India, 1994

University Appointment

Associate Professor

Professional Societies

American Thoracic Society

Research & Clinical Interests

My laboratory studies intracellular signaling regulating contraction, relaxation and proliferation of airway smooth muscle with particular emphasis on G protein coupled receptor mediated signaling. Current projects include understanding age-dependent changes in airway smooth muscle function (funded by NIA/NIH) and bitter taste receptor signaling in airway smooth muscle (funded by American Asthma Foundation). Airway smooth muscle is the principle contractile component of airways, and contraction and relaxation of ASM regulate airway diameter. Any alteration in ASM function results in bronchoconstriction and difficulty in breathing. Therefore, ASM acts as a primary therapeutic target in obstructive airway diseases such as asthma and COPD. Delineating novel receptors and signaling mechanisms that regulate ASM function would provide basis for developing newer and better drugs to treat asthma. 

Publications

Most Recent Peer-Reviewed Publications

  1. Mapping functional group free energy patterns at protein occluded sites: Nuclear receptors and g-protein coupled receptors
  2. β-agonist-mediated relaxation of airway smooth muscle is protein kinase A-dependent
  3. Mouse Models to Explore the Aging Lung
  4. Exploiting functional domains of GRK2/3 to alter the competitive balance of pro- and anticontractile signaling in airway smooth muscle
  5. Regulation of intracellular calcium by bitter taste receptors on airway smooth muscle
  6. CD38-cyclic ADP-ribose-mediated calcium signaling in airway myocytes
  7. A-kinase anchoring proteins regulate compartmentalized cAMP signaling in airway smooth muscle
  8. The GPCR OGR1 (GPR68) mediates diverse signalling and contraction of airway smooth muscle in response to small reductions in extracellular pH
  9. Reply to: Activation of BK channels may not be required for bitter tastant-induced bronchodilation
  10. Agonist-promoted homologous desensitization of human airway smooth muscle bitter taste receptors
  11. Bronchodilator activity of bitter tastants in human tissue
  12. Anti-mitogenic effects of β-agonists and PGE2on airway smooth muscle are PKA dependent
  13. Bitter taste receptors on airway smooth muscle bronchodilate by localized calcium signaling and reverse obstruction
  14. Glucocorticoid- and protein kinase A-dependent transcriptome regulation in airway smooth muscle
  15. Endogenous Gs-coupled receptors in smooth muscle exhibit differential susceptibility to GRK2/3-mediated desensitization
  16. β-Arrestins specifically constrain β2-adrenergic receptor signaling and function in airway smooth muscle
  17. Adenosine induces airway hyperresponsiveness through activation of A3 receptors on mast cells
  18. Mitogenic effects of cytokines on smooth muscle are critically dependent on protein kinase A and are unmasked by steroids and cyclooxygenase inhibitors
  19. PKC-dependent regulation of the receptor locus dominates functional consequences of cysteinyl leukotriene type 1 receptor activation
  20. Involvement of A1 adenosine receptors and neural pathways in adenosine-induced bronchoconstriction in mice