There are four immediate openings for post-doctoral fellows interested in cancer initiation in a well-funded, high-level cancer research laboratory. This laboratory recently moved to Philadelphia and now needs highly motivated postdoctoral fellows who will be defending their PhD soon or are not more than 2 years out of their PhD. Postdoctoral fellows should be interested in genetic, molecular, or biochemical mechanisms of tumor development. The laboratory utilizes genetically engineered mouse models, primary cell culture, retroviral gene transfer technologies, protein purification, genomics, bioinformatics, and patient sample analysis, to answer biological questions related to tumor initiation.
Project 1 focuses on Mdm2 and Mdmx and their p53-independent function in DNA break repair. This project involves biochemical, cellular, and mouse modeling approaches to characterize Mdm2 and Mdmx function in inhibiting DNA break repair and how this function can be capitalized on for the treatment of malignancies.
Project 2 is an investigation of Mtbp, a protein that regulates the Myc oncogenic transcription factor. A new mouse model and biochemical, cellular, genomic, and bioinformatic approaches are being used to elucidate its mechanism of action and its contribution to human lymphoma and other malignancies.
Project 3 is focused on lung adenocarcinoma and the miRNA that contribute to its development, growth, and progression. Mouse models and various approaches to evaluate miRNA and their targets are utilized.
Project 4 is an investigation of long non-coding (lnc) RNA in tumorigenesis. Multiple approaches to evaluate lncRNA and the genes/proteins they regulate in several different cancer types are utilized.
Interested individuals must be currently approved to work in the U.S. and be skilled in cancer biology techniques (e.g., cell culture, mouse modeling, biochemistry, flow cytometry, etc.)
Our organization values diversity and encourages applications from women, members of minority groups, LGBTQ individuals, disabled individuals, and veterans. In a single PDF document, applicants should submit a cover letter describing their qualifications and preferred project along with curriculum vitae, and list three professional references via email to email@example.com