Philadelphia University + Thomas Jefferson University
Sidney Kimmel Medical College
Department of Dermatology & Cutaneous Biology

Igoucheva, Olga

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Olga Igoucheva, PhD

Contact Dr. Igoucheva

Bluemle Life Sciences Building, Room 430
233 South Tenth Street
Philadelphia, PA 19107

(215) 503-5434
(215) 503-5788 fax

Research and Clinical Interests

adult stem cells; gene-, protein- and cell-based therapies; genodermatoses; congenital muscular dystrophy

Keywords

Adult stem cells; cDNA Microarrays; DNA Repair; Gene Correction; Gene Therapy; Oligodeoxynucleotides; RNA-DNA Oligonucleotides; Transcription; Extracellular matrix

Publications

Most Recent Peer-Reviewed Publications

  1. Pro-Inflammatory Chemokines and Cytokines Dominate the Blister Fluid Molecular Signature in Patients with Epidermolysis Bullosa and Affect Leukocyte and Stem Cell Migration
  2. Misbalanced CXCL12 and CCL5 Chemotactic Signals in Vitiligo Onset and Progression
  3. High concordance between clinical diagnosis of epidermolysis bullosa and immunofluorescence with a small, well-matched antibody panel
  4. Ladarixin, a dual CXCR1/2 inhibitor, attenuates experimental melanomas harboring different molecular defects by affecting malignant cells and tumor microenvironment
  5. Highly branched poly(β-amino ester)s for skin gene therapy
  6. Chemotaxis-driven disease-site targeting of therapeutic adult stem cells in dystrophic epidermolysis bullosa
  7. Fibulin-4 E57K knock-in mice recapitulate cutaneous, vascular and skeletal defects of recessive cutis laxa 1B with both elastic fiber and collagen fibril abnormalities
  8. Human adipose-derived stem cell transplantation as a potential therapy for collagen VI-related congenital muscular dystrophy
  9. Chemokine-enhanced DNA vaccination in cancer immunotherapy
  10. Immunotargeting and eradication of orthotopic melanoma using a chemokine-enhanced DNA vaccine
  11. Analysis of chemotactic molecules in bone marrow-derived mesenchymal stem cells and the skin: Ccl27-Ccr10 axis as a basis for targeting to cutaneous tissues
  12. Gene expression signatures of mouse bone marrow-derived mesenchymal stem cells in the cutaneous environment and therapeutic implications for blistering skin disorder
  13. A role for the Werner syndrome protein in epigenetic inactivation of the pluripotency factor Oct4
  14. Retroviral delivery of ECM genes.
  15. MicroRNA-dependent regulation of cKit in cutaneous melanoma
  16. Site-specific gene modification by oligodeoxynucleotides in mouse bone marrow-derived mesenchymal stem cells
  17. Protein therapeutics for junctional epidermolysis bullosa: Incorporation of recombinant β3 chain into laminin 332 in β3-/- keratinocytes in vitro
  18. Oligonucleotide-mediated gene targeting in human hepatocytes: Implications of mismatch repair
  19. Immunotherapeutic strategies for the treatment of malignant melanoma
  20. Characterization of the CCL21-mediated melanoma-specific immune responses and in situ melanoma eradication