Philadelphia University + Thomas Jefferson University
Sidney Kimmel Medical College
Department of Medicine

Horowitz, Arie

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Arie Horowitz, DSc

Arie Horowitz, DSc

Contact Dr. Horowitz

1020 Locust Street
Suite 394
Philadelphia, PA 19107

(215) 955-8017
(215) 955-9170 fax

Research & Clinical Interests

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My laboratory conducts basic research in vascular biology. Our objective is to understand how blood vessels regulate the permeability of their walls. Specifically, we study how the junctions between adjacent endothelial cells on the lumen of vessels are maintained, and how they respond to external stimuli, such as vascular endothelial growth factor. We pursue these questions by probing intracellular signaling pathways and protein complexes that determine the behavior of the junctions. We use cell culture and genetically modified mouse models in combination with advanced optical imaging techniques.

In addition to my membership in the Cardeza Center, I am an adjunct faculty in Cancer Biology, and a member of the Genetics, Genomics and Cancer Biology graduate program, and of the Sidney Kimmel Cancer Center in the Extracellular Matrix and Metastasis program.

Publications

Most Recent Peer-Reviewed Publications

  1. Plekhg5-regulated autophagy of synaptic vesicles reveals a pathogenic mechanism in motoneuron disease
  2. Analysis of retinoic acid-induced neural differentiation of mouse embryonic stem cells in two and three-dimensional embryoid bodies
  3. Letter by Horowitz Regarding Article, "protein Interactions at Endothelial Junctions and Signaling Mechanisms Regulating Endothelial Permeability"
  4. The versatility of RhoA activities in neural differentiation
  5. RhoA inhibits neural differentiation in murine stem cells through multiple mechanisms
  6. The cytoplasmic domain of neuropilin-1 regulates focal adhesion turnover
  7. VEGF and angiopoietin-1 exert opposing effects on cell junctions by regulating the Rho GEF Syx
  8. Stimulus-dependent phosphorylation of profilin-1 in angiogenesis
  9. Regulation of VEGF signaling by membrane traffic
  10. Rab13-dependent trafficking of RhoA is required for directional migration and angiogenesis
  11. Erratum: Vascular endothelial growth factor and semaphorin induce neuropilin-1 endocytosis via separate pathways (Circulation Research (2008) 103 (e71-e79))
  12. Imaging of growth factor-augmented angiogenesis after myocardial infarction: glimmers of a spatiotemporal pattern?
  13. Cleavage of syndecan-4 by ADAMTS1 provokes defects in adhesion
  14. Branching morphogenesis
  15. The Amot/Patj/Syx signaling complex spatially controls RhoA GTPase activity in migrating endothelial cells
  16. Branching morphogenesis
  17. Syx, a rhoA guanine exchange factor, is essential for angiogenesis in vivo
  18. Vascular endothelial growth factor and semaphorin induce neuropilin-1 endocytosis via separate pathways
  19. Directional cues in angiogenesis
  20. Erratum: Binding of internalized receptors to the PDZ domain of GIPC/synectin recruits myosin VI to endocytic vesicles (Proceedings of the National Academy of Sciences of the United States of America (August 22, 2006) 103, 34 (12735-12740) DOI: 10.1073/pnas.0605317103)