Thomas Jefferson University
Sidney Kimmel Medical College
Department of Medicine

McKenzie, Steven E.

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Steven E. McKenzie, MD, PhD

Contact Dr. McKenzie

1020 Locust Street
Suite 394
Philadelphia, PA 19107

215-955-3900
215-923-3836 fax

Research & Clinical Interests

Dr. McKenzie directs two major research projects. The first project involves vascular biology, with a focus on immune-mediated thrombocytopenia and thrombosis syndromes. This work, done in collaboration with Dr. Michael Reilly, led to the first model of heparin-induced thrombocytopenia and thrombosis. New work on effects of elevated cholesterol and athrosclerosis on HITT, and on microparticles and tissue factor, is ongoing.

Publications

Most Recent Peer-Reviewed Publications

  1. TULA-2 (T-Cell Ubiquitin Ligand-2) Inhibits the Platelet Fc Receptor for IgG IIA (FcγRIIA) Signaling Pathway and Heparin-Induced Thrombocytopenia in Mice
  2. TULA-2 protein phosphatase suppresses activation of syk through the GPVI platelet receptor for collagen by dephosphorylating Tyr(P)346 a regulatory site of syk
  3. Syk inhibition in ischemic stroke
  4. Anti-miR-148a regulates platelet FcγRIIA signaling and decreases thrombosis in vivo in mice
  5. Analysis of 13 cell types reveals evidence for the expression of numerous novel primate- And tissue-specific microRNAs
  6. Platelet 12-LOX is essential for FcγRIIa-mediated platelet activation
  7. MicroRNA expression differences in human hematopoietic cell lineages enable regulated transgene expression
  8. Human platelet microRNA-mRNA networks associated with age and gender revealed by integrated plateletomics
  9. The human platelet: Strong transcriptome correlations among individuals associate weakly with the platelet proteome
  10. Identification of a developmental gene expression signature, including hox genes, for the normal human colonic crypt stem cell niche: Overexpression of the signature parallels stem cell overpopulation during colon tumorigenesis
  11. Advances in the pathophysiology and treatment of heparin-induced thrombocytopenia
  12. CalDAG-GEFI deficiency protects mice from FcγRIIa-mediated thrombotic thrombocytopenia induced by CD40L and β2GPI immune complexes
  13. Tyrosine phosphorylation on spleen tyrosine kinase (Syk) is differentially regulated in human and murine platelets by protein kinase C isoforms
  14. MicroRNAs in platelet production and activation
  15. Cooperative integrin/ITAM signaling in platelets enhances thrombus formation in vitro and in vivo
  16. The complex transcriptional landscape of the anucleate human platelet
  17. Monocytes in HIT: An evolving story
  18. CalDAG-GEFI deficiency protects mice in a novel model of FcγRIIA-mediated thrombosis and thrombocytopenia
  19. Safety and pharmacokinetics of subcutaneously administered recombinant activated factor VII (rFVIIa)
  20. PRT-060318, a novel Syk inhibitor, prevents heparin-induced thrombocytopenia and thrombosis in a transgenic mouse model