Philadelphia University + Thomas Jefferson University
Sidney Kimmel Medical College
Department of Medicine

Deshpande, Deepak

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Deepak Deshpande, PhD

Contact Dr. Deshpande

1020 Locust Street
Room 543B
Philadelphia, PA 19107

(215) 955-3305
(215) 503-5731 fax

Education

PhD, College of Veterinary Medicine, University of Minnesota, 2004
MS, Veterinary College, University of Agricultural Sciences, Bangalore, India, 1997
DMV, Veterinary College, University of Agricultural Sciences, Bangalore, India, 1994

University Appointment

Associate Professor

Professional Societies

American Thoracic Society

Research & Clinical Interests

My laboratory studies intracellular signaling regulating contraction, relaxation and proliferation of airway smooth muscle with particular emphasis on G protein coupled receptor mediated signaling. Current projects include understanding age-dependent changes in airway smooth muscle function (funded by NIA/NIH) and bitter taste receptor signaling in airway smooth muscle (funded by American Asthma Foundation). Airway smooth muscle is the principle contractile component of airways, and contraction and relaxation of ASM regulate airway diameter. Any alteration in ASM function results in bronchoconstriction and difficulty in breathing. Therefore, ASM acts as a primary therapeutic target in obstructive airway diseases such as asthma and COPD. Delineating novel receptors and signaling mechanisms that regulate ASM function would provide basis for developing newer and better drugs to treat asthma. 

Publications

Most Recent Peer-Reviewed Publications

  1. Bitter Taste Receptor Agonists Mitigate Features of Allergic Asthma in Mice
  2. CD38 in the pathogenesis of allergic airway disease: Potential therapeutic targets
  3. An official American thoracic society research statement: Current challenges facing research and therapeutic advances in airway remodeling
  4. Bitter taste receptor agonists alter mitochondrial function and induce autophagy in airway smooth muscle cells
  5. Autophagy and airway fibrosis: Is there a link?
  6. Antimitogenic effect of bitter taste receptor agonists on airway smooth muscle cells
  7. Specificity of arrestin subtypes in regulating airway smooth muscle G protein-coupled receptor signaling and function
  8. Pleiotropic effects of bitter taste receptors on [Ca<sup>2+</sup>]<inf>i</inf> mobilization, hyperpolarization, and relaxation of human airway smooth muscle cells
  9. Mapping functional group free energy patterns at protein occluded sites: Nuclear receptors and g-protein coupled receptors
  10. IL-6 trans-signaling increases expression of airways disease genes in airway smooth muscle
  11. Regulation of intracellular calcium by bitter taste receptors on airway smooth muscle
  12. CD38-cyclic ADP-ribose-mediated calcium signaling in airway myocytes
  13. β-agonist-mediated relaxation of airway smooth muscle is protein kinase A-dependent
  14. Mouse Models to Explore the Aging Lung
  15. Exploiting functional domains of GRK2/3 to alter the competitive balance of pro- and anticontractile signaling in airway smooth muscle
  16. A-kinase anchoring proteins regulate compartmentalized cAMP signaling in airway smooth muscle
  17. The GPCR OGR1 (GPR68) mediates diverse signalling and contraction of airway smooth muscle in response to small reductions in extracellular pH
  18. Reply to: Activation of BK channels may not be required for bitter tastant-induced bronchodilation
  19. Agonist-promoted homologous desensitization of human airway smooth muscle bitter taste receptors
  20. Bronchodilator activity of bitter tastants in human tissue