Philadelphia University + Thomas Jefferson University
Sidney Kimmel Medical College
Department of Medicine

Pera, Tonio

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Tonio Pera, PhD

Contact Dr. Pera

1020 Locust Street
Jefferson Alumni Hall, Room 236
Philadelphia, PA 19107

(215) 503-5127
(215) 503-5731 fax

Education
PhD, University of Groningen in the Netherlands 2011

University Appointment
Assistant Professor

Professional Societies
American Thoracic Society

Research and Clinical Interests
Biased agonism of muscarinic M3 receptors in physiology and pathology of the lung.  G protein-coupled receptors (GPCRs) are crucial regulators of airway biology both in health and disease and are major targets of therapeutic drugs. The work in Dr. Pera’s lab combines expertise in airway physiology and pharmacology with GPCR biology and biochemistry with the goal of identifying GPCR ligands which exploit novel signaling mechanisms to treat obstructive lung diseases. Drug development for pulmonary obstructive diseases largely focused on refinement within the existing classes of drugs (corticosteroids, beta-agonists, and anticholinergics) and on the use of combinations of these. This strategy has led to enormous improvements in disease management in the past, but as various classes of drugs have reached their full potential this strategy will yield diminishing returns. The concept of biased agonism that has emerged recently indicates that certain ligands of GPCRs may not only turn receptors on or off but also induce qualitatively distinct signaling by the receptors.  Our research aims to utilize this novel concept of biased agonism to fine-tune receptor signaling so as to eliminate detrimental and promote beneficial signaling in the lung. Specifically, our current work involves identifying arrestin-biased muscarinic ligands and delineating muscarinic arrestin signaling in the lung.

Publications

Most Recent Peer-Reviewed Publications

  1. An official American thoracic society research statement: Current challenges facing research and therapeutic advances in airway remodeling
  2. Bronchoprotection and bronchorelaxation in asthma: New targets, and new ways to target the old ones
  3. Phosphodiesterase 4 inhibitors attenuate the asthma phenotype produced by β2-adrenoceptor agonists in phenylethanolamine N-methyltransferase-knockout mice
  4. Antimitogenic effect of bitter taste receptor agonists on airway smooth muscle cells
  5. Specificity of arrestin subtypes in regulating airway smooth muscle G protein-coupled receptor signaling and function
  6. Metformin attenuates hyperoxia-induced lung injury in neonatal rats by reducing the inflammatory response
  7. Crosstalk between beta-2-adrenoceptor and muscarinic acetylcholine receptors in the airway
  8. Arginase inhibition prevents Inflammation and Remodeling in a Guinea Pig model of Chronic obstructive Pulmonary disease
  9. Airway smooth muscle in asthma: Linking contraction and mechanotransduction to disease pathogenesis and remodelling
  10. Exploiting functional domains of GRK2/3 to alter the competitive balance of pro- and anticontractile signaling in airway smooth muscle
  11. Quaking, an RNA-binding protein, is a critical regulator of vascular smooth muscle cell phenotype
  12. Role for TAK1 in cigarette smoke-induced proinflammatory signaling and IL-8 release by human airway smooth muscle cells
  13. TAK1 plays a major role in growth factor-induced phenotypic modulation of airway smooth muscle
  14. Tiotropium inhibits pulmonary inflammation and remodelling in a guinea pig model of COPD
  15. Cigarette smoke and lipopolysaccharide induce a proliferative airway smooth muscle phenotype
  16. Arginase and pulmonary diseases
  17. Pharmacology of airway smooth muscle proliferation