Thomas Jefferson University
Sidney Kimmel Medical College
Department of Medicine

Wang, Bin

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Bin Wang, PhD

Contact Dr. Wang

1020 Locust Street
Jefferson Alumni Hall, Room 543
Philadelphia, PA 19107

(215) 503-8226
(215) 503-5731 fax

Medical School

PhD Pharmacology, Anhui Medical University, Hefei, China - 1999
MS Pharmacology, Anhui Medical University, Hefei, - 1993

University Appointment

Assistant Professor

Professional Societies

American Society for Bone and Mineral Research
The Endocrine Society
American College of Rheumatology

Research & Clinical Interests

Dr. Wang's laboratory is investigating the roles of parathyroid hormone (PTH)/PTH related protein (PTHrP)–activated PTH receptor in musculoskeletal diseases. Current projects include:

(1) Characterization of bimodal effects of PTH on bone metabolism. The long-term objective is to identify new compounds that can enhance the anabolic effect of PTH or PTHrP for the treatment of osteoporosis.

(2) Determining whether and how PTHrP plays a pathogenic role in articular cartilage degeneration (osteoarthritis) during aging.

(3) Characterization of the interaction of PTH receptor with other GPCRs. The purpose of this research will illustrate how PTH receptor coordinates with other GPCRs to maintain musculoskeletal homeostasis.

The overall mission of my research is to advance knowledge in the fields of GPCR biological and musculoskeletal disease research and translate the scientific discoveries into improved health.


Most Recent Peer-Reviewed Publications

  1. The proteasome inhibitor carfilzomib suppresses parathyroid hormone-induced osteoclastogenesis through a RANKL-mediated signaling pathway
  2. Disruption of ß-catenin binding to parathyroid hormone (PTH) receptor inhibits PTH-stimulated ERK1/2 activation
  3. Phosphorylation of ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) by Akt promotes stability and mitogenic function of S-phase kinase-associated protein-2 (Skp2)
  4. Astragaloside IV possesses antiarthritic effect by preventing interleukin 1β-induced joint inflammation and cartilage damage
  5. NHERF1 regulation of PTH-dependent bimodal Pi transport in osteoblasts
  6. Ezrin-anchored protein kinase A coordinates phosphorylation-dependent disassembly of a NHERF1 ternary complex to regulate hormone-sensitive phosphate transport
  7. Ubiquitination-deubiquitination balance dictates ligand-stimulated PTHR sorting
  8. Dynamic Na +-H + exchanger regulatory factor-1 association and dissociation regulate parathyroid hormone receptor trafficking at membrane microdomains
  9. A naturally occurring isoform inhibits parathyroid hormone receptor trafficking and signaling
  10. Formation of a ternary complex among NHERF1, β-arrestin, and parathyroid hormone receptor
  11. Na/H exchanger regulatory factors control parathyroid hormone receptor signaling by facilitating differential activation of Gα protein subunits
  12. Generation of human PTH1R construct with flag epitope located internally: Comparison of two-fragment assembly by using PCR overlap extension or ligase
  13. Sustained cyclic AMP production by parathyroid hormone receptor endocytosis
  14. NHERF1 regulates parathyroid hormone receptor desensitization: Interference with β-arrestin binding
  15. Na/H exchange regulatory factor 1, a novel AKT-associating protein, regulates extracellular signal-regulated kinase signaling through a B-Raf-mediated pathway
  16. NHERF1 regulates parathyroid hormone receptor membrane retention without affecting recycling
  17. NHERF-1 and the cytoskeleton regulate the traffic and membrane dynamics of G protein-coupled receptors
  18. Tyrosine kinase Etk/BMX is up-regulated in human prostate cancer and its overexpression induces prostate intraepithelial neoplasia in mouse
  19. Triptolide, an active component of the Chinese herbal remedy Tripterygium wilfordii Hook F, inhibits production of nitric oxide by decreasing inducible nitric oxide synthase gene transcription
  20. Anti-aging effect of astragalosides and its mechanism of action