Thomas Jefferson University
Sidney Kimmel Medical College
Department of Medicine

Chan, Tung

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Tung Chan

Tung Chan, PhD

Contact Dr. Chan

1025 Walnut Street
Suite 412
Philadelphia, PA 19107

(215) 955-4231
(215) 503-4741 fax


PhD University of Calgary, Alberta, Canada 1993

University Appointment

Assistant Professor of Medicine, 2003-current

Research & Clinical Interests

Dr. Chan's laboratory is investigating the roles of PI3K/Akt survival signals and adenosine G-protein-coupled receptors in heart failure development. Current projects include:

(1) Using an inducible and heart-specific promoter to activate adenosine receptors in mouse heart;

(2) Studying the contribution of individual Akt subtypes in heart failure development with Akt subtype-specific knockout mice;

(3) Using embryonic stem cells to determine novel mechanisms of Akt regulation and cardiomyocyte differentiation.

Dr. Chan believes that his research will help to advance heart disease therapeutics and to minimize cardiotoxic side effects of anti-cancer therapeutics.


Most Recent Peer-Reviewed Publications

  1. Akt kinase C-terminal modifications control activation loop dephosphorylation and enhance insulin response
  2. A truncated fragment of Src protein kinase generated by calpain-mediated cleavage is a mediator of neuronal death in excitotoxicity
  3. Coordinated regulation of cardiac Na+/Ca2+ exchanger and Na+-K+-ATPase by phospholemman (FXYD1)
  4. Induced overexpression of Na+/Ca2+ exchanger does not aggravate myocardial dysfunction induced by transverse aortic constriction
  5. Cardioprotection of controlled and cardiac-specific over-expression of a2A-adenosine receptor in the pressure overload
  6. Constitutive overexpression of phosphomimetic phospholemman S68E mutant results in arrhythmias, early mortality, and heart failure: Potential involvement of Na +/Ca 2+ exchanger
  7. Autoregulation of kinase dephosphorylation by ATP binding to AGC protein kinases
  8. Resistance of Akt kinases to dephosphorylation through ATP-dependent conformational plasticity
  9. Myocardial injury after ischemia-reperfusion in mice deficient in Akt2 is associated with increased cardiac macrophage density
  10. Adenosine receptor subtypes and the heart failure phenotype: translating lessons from mice to man.
  11. Residues 248-252 and 300-304 of the cardiac naspi +/Ca 2+ exchanger are involved in its regulation by phospholemman
  12. Controlled and cardiac-restricted overexpression of the arginine vasopressin V1A receptor causes reversible left ventricular dysfunction through Ga q-mediated cell signaling
  13. The interplay between NF-kappab and E2F1 coordinately regulates inflammation and metabolism in human cardiac cells
  14. Regulation of in vivo cardiac contractility by phospholemman: Role of Na+/Ca2+ exchange
  15. Left ventricular dysfunction in murine models of heart failure and in failing human heart is associated with a selective decrease in the expression of caveolin-3
  16. The p65 subunit of NF-B binds to PGC-1, linking inflammation and metabolic disturbances in cardiac cells
  17. Phospholemman: A novel cardiac stress protein
  18. Effects of cardiac-restricted overexpression of the A2A adenosine receptor on adriamycin-induced cardiotoxicity
  19. Phospholemman and β-adrenergic stimulation in the heart
  20. Induced overexpression of Na+/Ca2+ exchanger transgene: Altered myocyte contractility, [Ca2+]i transients, SR Ca2+ contents, and action potential duration