Thomas Jefferson University
Sidney Kimmel Medical College
Department of Medicine

Summer, Ross

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Ross Summer

Ross Summer, MD

Contact Dr. Summer

1025 Walnut Street
Suite 412
Philadelphia, PA 19107

(215) 503-3893
(215) 955-0830 fax

Medical School

Louisiana State University, New Orleans, LA

Residency

Johns Hopkins University

Fellowship

Boston University School of Medicine

Board Certification

Internal Medicine
Pulmonary Medicine
Critical Care Medicine

University Appointment

Associate Professor of Medicine

Clinical Interests

Acute lung injury
Interstitial lung disease
Dyspnea
General Pulmonary Medicine

Research & Clinical Interests

Dr. Summer is a board certified pulmonary and critical care physician and an NIH-funded basic science investigator. Work in his laboratory aims to understand the molecular and cellular mechanisms underlying cell and whole organ dysfunction in response to pulmonary insult. His work emphasizes the functional interconnections between cell signaling, metabolism and injury/repair mechanisms, and his laboratory applies a broad range of experimental approaches to characterize changes in the lung after acute (e.g., LPS, bleomycin, radiation) or chronic (e.g., obesity, chronic alcohol ingestion) pulmonary insult.  Dr. Summer’s clinical interests encompass a broad range of respiratory disorders but his outpatient clinical focus is in care and in the treatment of patients with fibrotic lung disease.

Publications

Most Recent Peer-Reviewed Publications

  1. Therapeutic advances in idiopathic pulmonary fibrosis
  2. C1q deficiency promotes pulmonary vascular inflammation and enhances the susceptibility of the lung endothelium to injury
  3. Obesity-induced adipokine imbalance impairs mouse pulmonary vascular endothelial function and primes the lung for injury
  4. Role of Angiotensin II type 1 receptor on renal NAD(P)H oxidase, oxidative stress and inflammation in nitric oxide inhibition induced-hypertension
  5. Direct effects of leptin and adiponectin on peripheral reproductive tissues: A critical review
  6. IL-15Rα is a determinant of muscle fuel utilization, and its loss protects against obesity
  7. A pneumocyte-macrophage paracrine lipid axis drives the lung toward fibrosis
  8. Plasma adiponectin, clinical factors, and patient outcomes during the acute respiratory distress syndrome
  9. Pleiotropic effects of cavin-1 deficiency on lipid metabolism
  10. Extracellular ATP mediates the late phase of neutrophil recruitment to the lung in murine models of acute lung injury
  11. Chronic alcohol ingestion in rats alters lung metabolism, promotes lipid accumulation, and impairs alveolar macrophage functions
  12. Scleroderma-related lung disease: Are Adipokines Involved Pathogenically?
  13. Obesity paradox?
  14. Obesity: "Priming" the lung for injury
  15. MicroRNA-638 is highly expressed in human vascular smooth muscle cells and inhibits PDGF-BB-induced cell proliferation and migration through targeting orphan nuclear receptor NOR1
  16. Cavin1; a Regulator of Lung Function and Macrophage Phenotype
  17. The adipokine adiponectin has potent anti-fibrotic effects mediated via adenosine monophosphate-activated protein kinase: Novel target for fibrosis therapy
  18. Acute respiratory distress syndrome: Epidemiology and management approaches
  19. Physician perception of the impact of productivity measures on academic practice
  20. Adiponectin attenuates lipopolysaccharide-induced acute lung injury through suppression of endothelial cell activation