3354 Summer, Ross - Thomas Jefferson University
Thomas Jefferson University
Sidney Kimmel Medical College
Department of Medicine

Summer, Ross

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Ross Summer

Ross Summer, MD

Contact Dr. Summer

1025 Walnut Street
Suite 412
Philadelphia, PA 19107

(215) 503-3893
(215) 955-0830 fax

Medical School

Louisiana State University, New Orleans, LA


Johns Hopkins University


Boston University School of Medicine

Board Certification

Internal Medicine
Pulmonary Medicine
Critical Care Medicine

University Appointment

Associate Professor of Medicine

Clinical Interests

Acute lung injury
Interstitial lung disease
General Pulmonary Medicine

Research & Clinical Interests

The major focus of Dr Summer's laboratory is on understanding the molecular interaction between lung and adipose tissue. It is now increasingly apparent that adipose tissue is not only a storage depot for fuel but also is an important endocrine organ. Endocrine activities of adipose tissue are mediated by hormones called adipokines, which act on distant tissues to regulate diverse biological processes. Recent work from Dr Summer's laboratory and that of others has identified key roles for adipokines in regulation of immune, vascular and smooth muscle homeostasis in the lung. Using genetic and diet-induced models to alter adipose tissue function, Dr. Summer's laboratory is hoping to better elucidate the role of these newly recognized hormones in lung health and disease.

Clinical Studies

Dr Summer is also involved in several clinical projects 2238 including investigations examining the impact of physician work targets on the performance of clinical (e.g. time at bedside, number of procedures) and non-clinical (e.g. teaching, research) activities as well as investigations into the factors contributing to diagnostic delays in patients with sepsis.


Most Recent Peer-Reviewed Publications

  1. Obesity-induced adipokine imbalance impairs mouse pulmonary vascular endothelial function and primes the lung for injury
  2. Role of Angiotensin II type 1 receptor on renal NAD(P)H oxidase, oxidative stress and inflammation in nitric oxide inhibition induced-hypertension
  3. A pneumocyte-macrophage paracrine lipid axis drives the lung toward fibrosis
  4. Direct effects of leptin and adiponectin on peripheral reproductive tissues: A critical review
  5. IL-15Rα is a determinant of muscle fuel utilization, and its loss protects against obesity
  6. Plasma adiponectin, clinical factors, and patient outcomes during the acute respiratory distress syndrome
  7. Pleiotropic effects of cavin-1 deficiency on lipid metabolism
  8. Extracellular ATP mediates the late phase of neutrophil recruitment to the lung in murine models of acute lung injury
  9. Chronic alcohol ingestion in rats alters lung metabolism, promotes lipid accumulation, and impairs alveolar macrophage functions
  10. Scleroderma-related lung disease: Are Adipokines Involved Pathogenically?
  11. Obesity paradox?
  12. Obesity: "Priming" the lung for injury
  13. MicroRNA-638 is highly expressed in human vascular smooth muscle cells and inhibits PDGF-BB-induced cell proliferation and migration through targeting orphan nuclear receptor NOR1
  14. Cavin1; a Regulator of Lung Function and Macrophage Phenotype
  15. The adipokine adiponectin has potent anti-fibrotic effects mediated via adenosine monophosphate-activated protein kinase: Novel target for fibrosis therapy
  16. Acute respiratory distress syndrome: Epidemiology and management approaches
  17. Physician perception of the impact of productivity measures on academic practice
  18. Adiponectin attenuates lipopolysaccharide-induced acute lung injury through suppression of endothelial cell activation
  19. Plasma adiponectin and mortality in critically ill subjects with acute respiratory failure
  20. Adiponectin promotes macrophage polarization toward an anti-inflammatory phenotype