Molecular cell biology of Nucleocytoplasmic Transport; X-ray crystallography and biophysical analysis of viral DNA-pumping machinery; structure of multi-subunit ATP synthases.

My laboratory uses X-ray crystallography, combined with biophysical and biochemical techniques to probe the structure and function of large macromolecular machines. We are interested in a variety of biological problems, which include the mechanisms and regulation of nucleocytoplasmic transport, the delivery of viral DNA into living cells, and the structure and regulation of multi-subunit ATP synthases. Our structural approach provides a unique tool to understand the function and engineer the activity of biological molecules. Visit our website (http://www.cingolanilab.org/) for more info.