Jianke Zhang, PhD
Professor, Department of Microbiology & Immunology
Contact
233 South 10th Street
Bluemle Life Sciences Building 731
Philadelphia, PA 19107
215-503-4559
215-503-4558 fax
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Jianke Zhang, PhD
Professor, Department of Microbiology & Immunology
Research & Clinical Interests
Immune tolerance and homeostasis; lymphocyte apoptosis; cytokine-receptor signal transduction; lymphocyte development; signal transduction mechanisms by the Fas/TNF receptor family members that mediate apoptosis and growth/proliferation; Toll-like receptor signaling; transgenic and gene targeting (knockout) analyses of protein functions in mice.
Publications
- Caspase-8 scaffolding function and MLKL regulate NLRP3 inflammasome activation downstream of TLR3
- Inhibition of Fas-Associated Death Domain-Containing Protein (FADD) Protects against Myocardial Ischemia/Reperfusion Injury in a Heart Failure Mouse Model
- Anti-MS4a4B treatment abrogates MS4a4B-mediated protection in T cells and ameliorates experimental autoimmune encephalomyelitis
- Autophagosomal membrane serves as platform for intracellular death-inducing signaling complex (iDISC)-mediated caspase-8 activation and apoptosis
- RIP1-mediated regulation of lymphocyte survival and death responses