Lucia R. Languino, PhD
Professor
Contact
Sidney Kimmel Cancer Center
233 S. Tenth Street, Suite 506
Philadelphia, PA 19107
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Lucia R. Languino, PhD
Professor
Education
PhD, Pharmacology, Negri Pharmacological Research Institute, Italy
Most Recent Peer-Reviewed Publications
- The NOGO receptor NgR2, a novel αVβ3 integrin effector, induces neuroendocrine differentiation in prostate cancer
- STEAP1–4 (Six-Transmembrane Epithelial Antigen of the Prostate 1–4) and Their Clinical Implications for Prostate Cancer
- Ghost mitochondria drive metastasis through adaptive GCN2/Akt therapeutic vulnerability
- Small extracellular vesicle-mediated ITGB6 siRNA delivery downregulates the αVβ6 integrin and inhibits adhesion and migration of recipient prostate cancer cells
- IFIT3 (interferon induced protein with tetratricopeptide repeats 3) modulates STAT1 expression in small extracellular vesicles
Expertise & Research Interests
Integrin and Growth Factor Receptor Signaling in Cancer
Dr. Languino investigates the role of cell adhesion receptors in phenotypic changes of prostate cancer cells. A strong research focus is being devoted to the study of the cross-talk between cancer cells and microenvironment mediated by extracellular vesicles and how this cross-talk affects intracellular signal transduction, cell survival, cell migration and cell division. Dr. Languino's research interests also focus on the cellular and molecular characterization of the metastatic process of prostate cancer with particular emphasis on the signals directing distant localization of prostate cancer cells.