The research projects cover different levels of organization, ranging from the investigation of subcellular events to whole organ physiology. Specific areas of research focus on the contractile process in smooth muscle, the organization of the contractile apparatus and how these are modified in disease states.  This includes a full analysis of the remodeling of smooth muscle that generally occurs in diseases, such as Diabetes, Parkinson’s Disease and Hirschsprung’s Disease. Approaches include determination of the chemical energetics and chemical regulation of smooth muscle contraction; contractile protein composition; mechanical properties including force production, ability and limits on shortening; regulation of crossbridge function; contractile filament organization; regulation by neural input; and underlying ultrastructural changes.