Philadelphia University + Thomas Jefferson University

Languino, Lucia

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Lucia R. Languino, PhD

Contact Dr. Languino

233 South 10th Street
Suite 506
Philadelphia, PA 19107

(215) 503-3442

Research and Clinical Interests

Studies of the signaling pathways that contribute to prostate cancer progression and metastasis.

Dr. Languino investigates the role of cell adhesion receptors in phenotypic changes of prostate cancer cells. A strong research focus is being devoted to the study of the cross-talk between cell adhesion molecules, extracellular matrix proteins and growth factor receptors in vitro and in vivo systems and how this cross-talk affects intracellular signal transduction, cell survival, cell migration and cell division. Dr. Languino's research interests also focus on the cellular and molecular characterization of the metastatic process of prostate cancer with particular emphasis on the signals directing distant localization of prostate cancer cells

Publications

Most Recent Peer-Reviewed Publications

  1. Exosomal αvβ6 integrin is required for monocyte M2 polarization in prostate cancer
  2. Cancer-Associated Fibroblasts Neutralize the Anti-tumor Effect of CSF1 Receptor Blockade by Inducing PMN-MDSC Infiltration of Tumors
  3. Syntaphilin controls a mitochondrial rheostat for proliferation-motility decisions in cancer
  4. c-Src, Insulin-Like Growth Factor I Receptor, G-Protein-Coupled Receptor Kinases and Focal Adhesion Kinase are Enriched Into Prostate Cancer Cell Exosomes
  5. A neuronal network of mitochondrial dynamics regulates metastasis
  6. Transgenic expression of the mitochondrial chaperone TNFR-associated protein 1 (TRAP1) accelerates prostate cancer development
  7. v-Src oncogene induces Trop2 proteolytic activation via cyclin D1
  8. Exosome-mediated transfer of αvβ3 integrin from tumorigenic to nontumorigenic cells promotes a migratory phenotype
  9. αvβ6 integrin promotes castrate-resistant prostate cancer through JNK1-mediated activation of androgen receptor
  10. Mitochondrial Akt Regulation of Hypoxic Tumor Reprogramming
  11. β1 integrin- and JNK-dependent tumor growth upon hypofractionated radiation
  12. The Mitochondrial Unfoldase-Peptidase Complex ClpXP Controls Bioenergetics Stress and Metastasis
  13. CD45 Phosphatase Inhibits STAT3 Transcription Factor Activity in Myeloid Cells and Promotes Tumor-Associated Macrophage Differentiation
  14. Exosome-mediated transfer from the tumor microenvironment increases TGFβ signaling in squamous cell carcinoma
  15. A microRNA/Runx1/Runx2 network regulates prostate tumor progression from onset to adenocarcinoma in TRAMP mice
  16. Deletion of Cyclophilin D Impairs β-Oxidation and Promotes Glucose Metabolism
  17. Expression of the IL-11 Gene in Metastatic Cells Is Supported by Runx2-Smad and Runx2-cJun Complexes Induced by TGFβ1
  18. Jak2-Stat5a/b Signaling Induces Epithelial-to-Mesenchymal Transition and Stem-Like Cell Properties in Prostate Cancer
  19. PI3K therapy reprograms mitochondrial trafficking to fuel tumor cell invasion
  20. Deregulation of MIR-34b/Sox2 predicts prostate cancer progression