Thomas Jefferson University
Jefferson College of Health Professions
Medical Laboratory Sciences & Biotechnology

Chadwick, Sean

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Profile

Sean Chadwick

Sean Chadwick, MS

Contact Mr. Chadwick

130 South Ninth Street
Edison Building, Suite 2120
Philadelphia, PA 19107

(215) 503-4246

Education

University of Medicine and Dentistry of New Jersey (New Rowan University), Stratford NJ - 2011
Richard Stockton College of New Jersey (now Stockton University), Galloway NJ - 2006

Focus

Biotechnology

University Appointment

Biotechnology Instructor, 2019

Research & Clinical Interest

Much of my past research focused on mechanisms of antimicrobial resistance in organisms such as Candida glabrata and Staphylococcus aureus. This research led to the development of novel diagnostic assays to rapidly detect these organisms to facilitate proper treatment. Diagnostic research spread into the field of polymicrobial infections, next generation sequencing and informative diagnostics. I worked for the NJ Department of Agriculture Animal Health Research Laboratory as the section head of the virology and serology department, and oversaw diagnostic testing while developing and improving molecular detection assays. I also have experience in the pharmaceutical industry, and spent 4 years on a major biologic therapeutic drug product. Research focused on manufacturing robustness, shelf life extension, and validation of alternative packaging components.

Publications

Most Recent Peer-Reviewed Publications

  1. Utilization of molecular methods to identify prognostic markers for recurrent bacterial vaginosis
  2. Erratum: Development and validation of a highly accurate quantitative real-time PCR assay for diagnosis of bacterial vaginosis (Journal of Clinical Microbiology (2016) 54:4 (1017-1024))
  3. Development and validation of a highly accurate quantitative real- time PCR assay for diagnosis of bacterial vaginosis
  4. Draft genome sequence of a metronidazole-resistant Gardnerella vaginalis isolate
  5. UPC2A is required for high-level azole antifungal resistance in Candida glabrata
  6. Detection of epidemic USA300 community-associated methicillin-resistant Staphylococcus aureus strains by use of a single allele-specific PCR assay targeting a novel polymorphism of Staphylococcus aureus pbp3
  7. X-Plate Technology:A new method for detecting fluconazole resistance in Candida species
  8. Staphylococcal Cassette Chromosome mec type and antibiotic susceptibility profiles of vaginal and nonvaginal MRSA clinical isolates
  9. Gain-of-function mutations in UPC2 are a frequent cause of ERG11 upregulation in azole-resistant clinical isolates of Candida albicans
  10. Arv1 lipid transporter function is conserved between pathogenic and nonpathogenic fungi
  11. Antifungal resistance of Candida glabrata vaginal isolates and development of a quantitative reverse transcription-PCR-based azole susceptibility assay
  12. Survey of vaginal-flora Candida species isolates from women of different age groups by use of species-specific PCR detection