esa101

Emad Alnemri, PhD

Contact Dr. Alnemri

233 South 10th Street
Bluemle Life Sciences Building Room 904
Philadelphia, PA 19107

(215) 503-4632
(215) 923-1098 fax

Most Recent Peer-reviewed Publications

  1. Tristetraprolin regulates necroptosis during tonic Toll-like receptor 4 (TLR4) signaling in murine macrophages
  2. Mutant BRAF and MEK inhibitors regulate the tumor immune microenvironment via pyroptosis
  3. Gasdermins in apoptosis: New players in an old game
  4. Gasdermin pores permeabilize mitochondria to augment caspase-3 activation during apoptosis and inflammasome activation
  5. Gasdermins: novel mitochondrial pore-forming proteins
  6. The mitochondrial protease HtrA2 restricts the NLRP3 and AIM2 inflammasomes
  7. SUMO-mediated regulation of NLRP3 modulates inflammasome activity
  8. The NLRP6 Inflammasome Recognizes Lipoteichoic Acid and Regulates Gram-Positive Pathogen Infection
  9. Triad3a induces the degradation of early necrosome to limit RipK1-dependent cytokine production and necroptosis article
  10. Molecular mechanisms of cell death: Recommendations of the Nomenclature Committee on Cell Death 2018
  11. Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic/pyroptotic cell death
  12. The Yersinia pestis Effector YopM Inhibits Pyrin Inflammasome Activation
  13. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
  14. Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356
  15. Caspase-8 scaffolding function and MLKL regulate NLRP3 inflammasome activation downstream of TLR3
  16. Non-transcriptional regulation of NLRP3 inflammasome signaling by IL-4
  17. The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease
  18. Essential versus accessory aspects of cell death: Recommendations of the NCCD 2015
  19. Inflammasome priming by lipopolysaccharide is dependent upon ERK signaling and proteasome function
  20. Inactivation of Omi/HtrA2 protease leads to the deregulation of mitochondrial Mulan E3 ubiquitin ligase and increased mitophagy
  21. IKKα negatively regulates ASC-dependent inflammasome activation
  22. Cutting edge: TLR signaling licenses IRAK1 for rapid activation of the NLRP3 inflammasome
  23. The mitochondrial antiviral protein MAVS associates with NLRP3 and regulates its inflammasome activity
  24. Restoration of ASC expression sensitizes colorectal cancer cells to genotoxic stress-induced caspase-independent cell death
  25. Ribotoxic stress through p38 mitogen-activated protein kinase activates in Vitro the human pyrin inflammasome