jlb104

Jeffrey L. Benovic, PhD

Contact Dr. Benovic

233 South 10th Street
Bluemle Life Sciences Building, Room 926/930
Philadelphia, PA 19107

(215) 503-4607
(215) 503-5393 fax

Most Recent Peer-reviewed Publications

  1. Biased agonism at β-adrenergic receptors
  2. Historical Perspective of the G Protein-Coupled Receptor Kinase Family
  3. Targeting G protein–coupled receptor kinases to G protein–coupled receptors
  4. Structure of a GRK5-Calmodulin Complex Reveals Molecular Mechanism of GRK Activation and Substrate Targeting
  5. Arresting Developments in Biased Signaling
  6. GRK6 regulates the hemostatic response to injury through its rate-limiting effects on GPCR signaling in platelets
  7. G protein-coupled receptor kinase 5 modifies cancer cell resistance to paclitaxel
  8. Effects of oncogenic Gαq and Gα11 inhibition by FR900359 in uveal melanoma
  9. Emerging Paradigm of Intracellular Targeting of G Protein-Coupled Receptors
  10. Pepducins as a potential treatment strategy for asthma and COPD
  11. Biased signaling of the proton-sensing receptor OGR1 by benzodiazepines
  12. Pepducin-mediated cardioprotection via β-arrestin-biased β2-adrenergic receptor-specific signaling
  13. G protein-coupled receptor kinases: Past, present and future
  14. G protein-coupled receptor kinase 3 and protein kinase C phosphorylate the distal C-terminal tail of the chemokine receptor CXCR4 and mediate recruitment of β-arrestin
  15. Structural basis for ß-arrestins in gpcr trafficking
  16. Dysregulated GPCR signaling and therapeutic options in uveal melanoma
  17. Structural and Functional Analysis of a β2-Adrenergic Receptor Complex with GRK5
  18. G protein-coupled receptor kinase-2 (GRK-2) regulates serotonin metabolism through the monoamine oxidase AMX-2 in Caenorhabditis elegans
  19. c-Src, Insulin-Like Growth Factor I Receptor, G-Protein-Coupled Receptor Kinases and Focal Adhesion Kinase are Enriched Into Prostate Cancer Cell Exosomes
  20. β-arrestin-biased signaling through the β2-adrenergic receptor promotes cardiomyocyte contraction
  21. The αarrestin ARRDC3 regulates the endosomal residence time and intracellular signaling of the β2-adrenergic receptor
  22. From biased signalling to polypharmacology: Unlocking unique intracellular signalling using pepducins
  23. Interdicting Gq activation in airway disease by receptor-dependent and receptor-independent mechanisms
  24. Atomic structure of GRK5 reveals distinct structural features novel for G protein-coupled receptor kinases
  25. Structural biology: Arresting developments in receptor signalling