Gino Cingolani, PhD

Contact Dr. Cingolani

1020 Locust Street
Jefferson Alumni Hall, Room 411K
Philadelphia, PA 19107

(215) 503-4573
(215) 923-2117 fax

Most Recent Peer-reviewed Publications

  1. Expression and purification of phage T7 ejection proteins for cryo-EM analysis
  2. Three-dimensional structure of human cyclooxygenase (hCOX)-1
  3. Cryo-EM structure of the periplasmic tunnel of T7 DNA-ejectosome at 2.7 Å resolution
  4. Learning from Nature: From a Marine Natural Product to Synthetic Cyclooxygenase-1 Inhibitors by Automated De Novo Design
  5. Biophysical analysis of Pseudomonas-phage PaP3 small terminase suggests a mechanism for sequence-specific DNA-binding by lateral interdigitation
  6. Recognition of an α-helical hairpin in P22 large terminase by a synthetic antibody fragment
  7. Lyssavirus Vaccine with a Chimeric Glycoprotein Protects across Phylogroups
  8. Selective inhibition of Ph-positive ALL cell growth through kinase-dependent and -independent effects by CDK6-specific PROTACs
  9. Heme and hemoglobin utilization by Mycobacterium tuberculosis
  10. Structural basis for the homotypic fusion of chlamydial inclusions by the SNARE-like protein IncA
  11. Portal Protein: The Orchestrator of Capsid Assembly for the dsDNA Tailed Bacteriophages and Herpesviruses
  12. DNA Conformational Changes Play a Force-Generating Role during Bacteriophage Genome Packaging
  13. Molecular Architecture of the Inositol Phosphatase Siw14
  14. RNA Recognition-like Motifs Activate a Mitogen-Activated Protein Kinase
  15. A Tail of Phage Adhesins
  16. Nuclear Pores Promote Lethal Prostate Cancer by Increasing POM121-Driven E2F1, MYC, and AR Nuclear Import
  17. Breaking symmetry in viral icosahedral capsids as seen through the lenses of X-ray crystallography and cryo-electron microscopy
  18. Three-dimensional context rather than NLS amino acid sequence determines importin α subtype specificity for RCC1
  19. Synergy of two low-affinity NLSs determines the high avidity of influenza A virus nucleoprotein NP for human importin α isoforms
  20. A viral scaffolding protein triggers portal ring oligomerization and incorporation during procapsid assembly
  21. Portal protein functions akin to a DNA-sensor that couples genome-packaging to icosahedral capsid maturation
  22. Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic/pyroptotic cell death
  23. Structural basis for selective inhibition of Cyclooxygenase-1 (COX-1) by diarylisoxazoles mofezolac and 3-(5-chlorofuran-2-yl)-5-methyl-4-phenylisoxazole (P6)
  24. Divergent evolution of nuclear localization signal sequences in herpesvirus terminase subunits
  25. Structural plasticity of the protein plug that traps newly packaged genomes in podoviridae virions