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Gino Cingolani, PhD

Contact Dr. Cingolani

1020 Locust Street
Jefferson Alumni Hall, Room 411K
Philadelphia, PA 19107

(215) 503-4573
(215) 923-2117 fax

Most Recent Peer-reviewed Publications

  1. Three-dimensional structure of human cyclooxygenase (hCOX)-1
  2. Cryo-EM structure of the periplasmic tunnel of T7 DNA-ejectosome at 2.7 Å resolution
  3. Learning from Nature: From a Marine Natural Product to Synthetic Cyclooxygenase-1 Inhibitors by Automated De Novo Design
  4. Biophysical analysis of Pseudomonas-phage PaP3 small terminase suggests a mechanism for sequence-specific DNA-binding by lateral interdigitation
  5. Recognition of an α-helical hairpin in P22 large terminase by a synthetic antibody fragment
  6. Lyssavirus Vaccine with a Chimeric Glycoprotein Protects across Phylogroups
  7. Selective inhibition of Ph-positive ALL cell growth through kinase-dependent and -independent effects by CDK6-specific PROTACs
  8. Heme and hemoglobin utilization by Mycobacterium tuberculosis
  9. Structural basis for the homotypic fusion of chlamydial inclusions by the SNARE-like protein IncA
  10. Portal Protein: The Orchestrator of Capsid Assembly for the dsDNA Tailed Bacteriophages and Herpesviruses
  11. DNA Conformational Changes Play a Force-Generating Role during Bacteriophage Genome Packaging
  12. Molecular Architecture of the Inositol Phosphatase Siw14
  13. RNA Recognition-like Motifs Activate a Mitogen-Activated Protein Kinase
  14. A Tail of Phage Adhesins
  15. Nuclear Pores Promote Lethal Prostate Cancer by Increasing POM121-Driven E2F1, MYC, and AR Nuclear Import
  16. Breaking symmetry in viral icosahedral capsids as seen through the lenses of X-ray crystallography and cryo-electron microscopy
  17. Three-dimensional context rather than NLS amino acid sequence determines importin α subtype specificity for RCC1
  18. Synergy of two low-affinity NLSs determines the high avidity of influenza A virus nucleoprotein NP for human importin α isoforms
  19. A viral scaffolding protein triggers portal ring oligomerization and incorporation during procapsid assembly
  20. Portal protein functions akin to a DNA-sensor that couples genome-packaging to icosahedral capsid maturation
  21. Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic/pyroptotic cell death
  22. Structural basis for selective inhibition of Cyclooxygenase-1 (COX-1) by diarylisoxazoles mofezolac and 3-(5-chlorofuran-2-yl)-5-methyl-4-phenylisoxazole (P6)
  23. Divergent evolution of nuclear localization signal sequences in herpesvirus terminase subunits
  24. Structural plasticity of the protein plug that traps newly packaged genomes in podoviridae virions
  25. PARP-2 domain requirements for DNA damage-dependent activation and localization to sites of DNA damage