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Diane E. Merry, PhD

Contact Dr. Merry

233 South 10th Street
228 BLSB
Philadelphia, PA 19107

(215) 503-4907
(215) 923-9162 fax

Most Recent Peer-reviewed Publications

  1. Fluorescence Imaging of Huntingtin mRNA Knockdown
  2. The 11s proteasomal activator reg╬│ impacts polyglutamine-expanded androgen receptor aggregation and motor neuron viability through distinct mechanisms
  3. The polyglutamine-expanded androgen receptor responsible for spinal and bulbar muscular atrophy inhibits the APC/CCdh1ubiquitin ligase complex
  4. Identification of novel polyglutamine-expanded aggregation species in spinal and bulbar muscular atrophy
  5. Proteasome-mediated Proteolysis of the polyglutamine-expanded androgen receptor is a late event in spinal and bulbar muscular atrophy (SBMA) pathogenesis
  6. Inhibition of Stat5a/b enhances proteasomal degradation of androgen receptor liganded by antiandrogens in prostate cancer
  7. Disrupting SUMOylation enhances transcriptional function and ameliorates polyglutamine androgen receptor-mediated disease
  8. Behavioral phenotypes in males with XYY and possible role of increased NLGN4Y expression in autism features
  9. Preventing the Androgen Receptor N/C Interaction Delays Disease Onset in a Mouse Model of SBMA
  10. Transcriptional activation of TFEB/ZKSCAN3 target genes underlies enhanced autophagy in spinobulbar muscular atrophy
  11. Cell biological approaches to investigate polyglutamine-expanded AR metabolism
  12. Activation of Hsp70 reduces neurotoxicity by promoting polyglutamine protein degradation
  13. Attacking the flank: Targeting new pathways in SBMA
  14. A polyglutamine expansion disease protein sequesters PTIP to attenuate DNA repair and increase genomic instability
  15. Guidelines for the use and interpretation of assays for monitoring autophagy
  16. Testosterone treatment fails to accelerate disease in a transgenic mouse model of spinal and bulbar muscular atrophy
  17. SIRT1 modulates aggregation and toxicity through deacetylation of the androgen receptor in cell models of SBMA
  18. An interdomain interaction of the androgen receptor is required for its aggregation and toxicity in spinal and bulbar muscular atrophy
  19. Autophagy and access: Understanding the role of androgen receptor subcellular localization in SBMA
  20. FOXO3a is broadly neuroprotective in vitro and in vivo against insults implicated in motor neuron diseases