rxp618

Richard Pomerantz, PhD

Contact Dr. Pomerantz

233 South 10th St
Bluemle Life Sciences Building Room 915
Philadelphia, PA 19107


Most Recent Peer-reviewed Publications

  1. Dna polymerase θ: A cancer drug target with reverse transcriptase activity
  2. Polθ reverse transcribes RNA and promotes RNA-templated DNA repair
  3. Polθ promotes the repair of 5′-DNA-protein crosslinks by microhomology-mediated end-joining
  4. Publisher Correction: Molecular basis of microhomology-mediated end-joining by purified full-length Polθ (Nature Communications, (2019), 10, 1, (4423), 10.1038/s41467-019-12272-9)
  5. Molecular basis of microhomology-mediated end-joining by purified full-length Polθ
  6. One-step enzymatic modification of RNA 3 termini using polymerase
  7. Identification of a Small Interface between the Methyltransferase and RNA Polymerase of NS5 that is Essential for Zika Virus Replication
  8. How RNA transcripts coordinate DNA recombination and repair
  9. Large deletions induced by Cas9 cleavage
  10. Polymerase θ-helicase efficiently unwinds DNA and RNA-DNA hybrids
  11. PARP1 restricts Epstein Barr Virus lytic reactivation by binding the BZLF1 promoter
  12. The helicase domain of Polθ counteracts RPA to promote alt-NHEJ
  13. DNA polymerase θ specializes in incorporating synthetic expanded-size (xDNA) nucleotides
  14. DNA polymerase θ: A unique multifunctional end-joining machine
  15. Polymerase θ is a robust terminal transferase that oscillates between three different mechanisms during end-joining
  16. Small-Molecule Disruption of RAD52 Rings as a Mechanism for Precision Medicine in BRCA-Deficient Cancers
  17. Mechanism of microhomology-mediated end-joining promoted by human DNA polymerase θ
  18. DNA polymerases are error-prone at RecA-mediated recombination intermediates
  19. Preferential D-loop extension by a translesion DNA polymerase underlies error-prone recombination
  20. What happens when replication and transcription complexes collide?
  21. Direct restart of a replication fork stalled by a head-on RNA polymerase
  22. Direct restart of a replication fork stalled by a head-on RNA polymerase
  23. Polymerase trafficking: A role for transcription factors in preventing replication fork arrest
  24. The replisome uses mRNA as a primer after colliding with RNA polymerase
  25. Replisome mechanics: insights into a twin DNA polymerase machine