Philip B. Wedegaertner, PhD

Contact Dr. Wedegaertner

233 South 10th Street
839 BLSB
Philadelphia, PA 19107

(215) 503-3137

Most Recent Peer-reviewed Publications

  1. G protein-coupled receptor kinase 4-induced cellular senescence and its senescence-associated gene expression profiling
  2. Functional selectivity of GPCR-directed drug action through location bias
  3. Dysregulated GPCR signaling and therapeutic options in uveal melanoma
  4. Inducible inhibition of Gβγ reveals localization-dependent functions at the plasma membrane and Golgi
  5. Mitotic-dependent phosphorylation of leukemia-associated RhoGEF (LARG) by Cdk1
  6. PAQR3 regulates Golgi vesicle fission and transport via the Gβγ-PKD signaling pathway
  7. G protein βγ subunits regulate cardiomyocyte hypertrophy through a perinuclear Golgi phosphatidylinositol 4-phosphate hydrolysis pathway
  8. The regulator of G protein signaling (RGS) domain of G protein-coupled receptor kinase 5 (GRK5) regulates plasma membrane localization and function
  9. Leukemia-associated RhoGEF (LARG) is a novel RhoGEF in cytokinesis and required for the proper completion of abscission
  10. G protein trafficking.
  11. Non-canonical signaling and localizations of heterotrimeric G proteins
  12. Reversible palmitoylation in g protein signaling
  13. Regulation of constitutive cargo transport from the trans-Golgi network to plasma membrane by Golgi-localized G protein βγ subunits
  14. An N-terminal polybasic motif of Gαqis required for signaling and influences membrane nanodomain distribution
  15. The amino acid motif L/IIxxFE defines a novel actin-binding sequence in PDZ-RhoGEF
  16. Differences in Gα12- and Gα13-mediated plasma membrane recruitment of p115-RhoGEF
  17. N-terminal polybasic motifs are required for plasma membrane localization of Gαs and Gαq
  18. FAK, PDZ-RhoGEF and ROCKII cooperate to regulate adhesion movement and trailing-edge retraction in fibroblasts
  19. Disruption of oligomerization induces nucleocytoplasmic shuttling of leukemia-associated Rho guanine-nucleotide exchange factor
  20. Plasma membrane and nuclear localization of G protein-coupled receptor kinase 6A