233 S. Tenth Street, Suite 506
Philadelphia, PA 19107
(215) 503-3442
Most Recent Peer-reviewed Publications
- Exosomal αvβ6 integrin is required for monocyte M2 polarization in prostate cancer
- Syntaphilin ubiquitination regulates mitochondrial dynamics and tumor cell movements
- Evaluation of Drug Combination Effect Using a Bliss Independence Dose–Response Surface Model
- Cancer-Associated Fibroblasts Neutralize the Anti-tumor Effect of CSF1 Receptor Blockade by Inducing PMN-MDSC Infiltration of Tumors
- Syntaphilin controls a mitochondrial rheostat for proliferation-motility decisions in cancer
Education
PhD, Pharmacology, Negri Pharmacological Research Institute, Italy
Expertise & Research Interests
Integrin and Growth Factor Receptor Signaling in Cancer
Dr. Languino investigates the role of cell adhesion receptors in phenotypic changes of prostate cancer cells. A strong research focus is being devoted to the study of the cross-talk between cell adhesion molecules, extracellular matrix proteins and growth factor receptors in vitro and in vivo systems and how this cross-talk affects intracellular signal transduction, cell survival, cell migration and cell division. Dr. Languino's research interests also focus on the cellular and molecular characterization of the metastatic process of prostate cancer with particular emphasis on the signals directing distant localization of prostate cancer cells.