233 S. Tenth Street, Suite 506
Philadelphia, PA 19107
(215) 503-3442
Most Recent Peer-reviewed Publications
- Identification of monocyte-like precursors of granulocytes in cancer as a mechanism for accumulation of PMN-MDSCs
- Myc Regulation of a Mitochondrial Trafficking Network Mediates Tumor Cell Invasion and Metastasis
- Tumor-Derived Extracellular Vesicles Require β1 Integrins to Promote Anchorage-Independent Growth
- Activated Extracellular Vesicles as New Therapeutic Targets?
- Prostate cancer sheds the αvβ3 integrin in vivo through exosomes
Education
PhD, Pharmacology, Negri Pharmacological Research Institute, Italy
Expertise & Research Interests
Integrin and Growth Factor Receptor Signaling in Cancer
Dr. Languino investigates the role of cell adhesion receptors in phenotypic changes of prostate cancer cells. A strong research focus is being devoted to the study of the cross-talk between cell adhesion molecules, extracellular matrix proteins and growth factor receptors in vitro and in vivo systems and how this cross-talk affects intracellular signal transduction, cell survival, cell migration and cell division. Dr. Languino's research interests also focus on the cellular and molecular characterization of the metastatic process of prostate cancer with particular emphasis on the signals directing distant localization of prostate cancer cells.