Dr. Mastrangelo

Michael J. Mastrangelo, MD

Contact Dr. Mastrangelo

925 Chestnut Street
Suite 220A
Philadelphia, PA 19107

(215) 955-8874

Medical School

Johns Hopkins University School of Medicine - 1964


Thomas Jefferson University Hospital - 1970-1971


Thomas Jefferson University Hospital - 1969-1970

Board Certification

Medical Oncology
Internal Medicine

Hospital Appointment

Thomas Jefferson University Hospital
Methodist Hospital Division of Thomas Jefferson University Hospital

University Appointment


Research & Clinical Interests

Medical Oncology, Melanoma, Skin Cancer

Dr. Mastrangelo is internationally recognized for his work in melanoma, and limits his practice to advanced cutaneous malignancies, especially cutaneous melanoma. In addition to collaborating with Dr. David Berd in the development of the autologous melanoma vaccine, Dr. Mastrangelo has also worked to explore the use of topical/intralesional wild-type and recombinant (GM-CSF) vaccinia viruses in the treatment of malignant melanoma and bladder cancer. His professional objectives are to improve the clinical outcome for patients with cutaneous melanoma through a better understanding of the biology of the disease, especially as it relates to tumor-host interactions. His clinical research has focused on intralesional therapy with microbial products, especially recombinant oncolytic viruses.