Yuri Sykulev, MD, PhD

Contact Dr. Sykulev

233 S. 10th Street
Room 706
Philadelphia, PA 19107

(215) 503-4530

Most Recent Peer-reviewed Publications

  1. Efficient killing of tumor cells by CAR-T cells requires greater number of engaged CARs than TCRs
  2. The DISC1–Girdin complex – a missing link in signaling to the T cell cytoskeleton
  3. Protective Allele for Multiple Sclerosis HLA-DRB1*01:01 Provides Kinetic Discrimination of Myelin and Exogenous Antigenic Peptides
  4. Extent of MHC clustering regulates selectivity and effectiveness of T cell responses
  5. Assessment of the synaptic interface of primary human t cells from peripheral blood and lymphoid tissue
  6. Limited immune surveillance in lymphoid tissue by cytolytic CD4+ T cells during health and HIV disease
  7. Evaluating frequency and quality of pathogen-specific T cells
  8. Integrins influence the size and dynamics of signaling microclusters in a Pyk2-dependent manner
  9. Herman N. Eisen: Mentor to many
  10. Integrin receptors on tumor cells facilitate NK cell-mediated antibody-dependent cytotoxicity
  11. Evidence that the density of self peptide-MHC ligands regulates T-cell receptor signaling
  12. Enteric alpha defensins in norm and pathology
  13. Role of the MTOC in T cell effector functions
  14. The mechanisms of inactivation of the Tag7-Hsp70 cytotoxic complex
  15. Mechanisms controlling granule-mediated cytolytic activity of cytotoxic T lymphocytes
  16. Quantum dots as a unique nanoscaffold to mimic membrane receptor clustering
  17. T cell receptor signaling kinetics takes the stage
  18. A novel composite immunotoxin that suppresses rabies virus production by the infected cells
  19. Changing separating distances between immune receptors as a sensitive mechanism regulating T-cell activation
  20. Kinetics of Early T Cell Receptor Signaling Regulate the Pathway of Lytic Granule Delivery to the Secretory Domain
  21. Can oligomeric T-cell receptor be used as a tool to detect viral peptide epitopes on infected cells?
  22. How a T cell receptor-like antibody recognizes major histocompatibility complex-bound peptide
  23. Protein kinase Cθ regulates stability of the peripheral adhesion ring junction and contributes to the sensitivity of target cell lysis by CTL
  24. Tpl2 and ERK transduce antiproliferative T cell receptor signals and inhibit transformation of chronically stimulated T cells
  25. Quantum dot/peptide-MHC biosensors reveal strong CD8-dependent cooperation between self and viral antigens that augment the T cell response