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Piera Pasinelli, PhD

Contact Dr. Pasinelli

900 Walnut Street
JHN 4th floor
Philadelphia, PA 19107

(215) 955-8394
(215) 503-4358 fax

Most Recent Peer-reviewed Publications

  1. Synaptic dysfunction induced by glycine-alanine dipeptides in C9orf72-ALS/FTD is rescued by SV2 replenishment
  2. AAV2-BDNF promotes respiratory axon plasticity and recovery of diaphragm function following spinal cord injury
  3. Muscleblind acts as a modifier of FUS toxicity by modulating stress granule dynamics and SMN localization
  4. Excess glutamate secreted from astrocytes drives upregulation of P-glycoprotein in endothelial cells in amyotrophic lateral sclerosis
  5. Repeat-associated non-AUG translation in C9orf72-ALS/FTD is driven by neuronal excitation and stress
  6. Astrocytes expressing ALS-linked mutant FUS induce motor neuron death through release of tumor necrosis factor-alpha
  7. Blood–Brain Barrier Driven Pharmacoresistance in Amyotrophic Lateral Sclerosis and Challenges for Effective Drug Therapies
  8. Mutation of the caspase-3 cleavage site in the astroglial glutamate transporter EAAT2 delays disease progression and extends lifespan in the SOD1-G93A mouse model of ALS
  9. Pathogenic determinants and mechanisms of ALS/FTD linked to hexanucleotide repeat expansions in the C9orf72 gene
  10. Cell-to-Cell Transmission of Dipeptide Repeat Proteins Linked to C9orf72-ALS/FTD
  11. Astrocytes drive upregulation of the multidrug resistance transporter ABCB1 (P-Glycoprotein) in endothelial cells of the blood–brain barrier in mutant superoxide dismutase 1-linked amyotrophic lateral sclerosis
  12. Pur-alpha regulates cytoplasmic stress granule dynamics and ameliorates FUS toxicity
  13. Regulation of ABC efflux transporters at blood-brain barrier in health and neurological disorders
  14. ABC transporter-driven pharmacoresistance in Amyotrophic Lateral Sclerosis
  15. Inhibiting drug efflux transporters improves efficacy of ALS therapeutics
  16. Role of mitochondria in mutant SOD1 linked amyotrophic lateral sclerosis
  17. Sumoylation of the astroglial glutamate transporter EAAT2 governs its intracellular compartmentalization
  18. Antisense proline-arginine RAN dipeptides linked to C9ORF72-ALS/FTD form toxic nuclear aggregates that initiate invitro and invivo neuronal death
  19. Defects in synapse structure and function precede motor neuron degeneration in Drosophila models of FUS-related ALS
  20. Small peptides against the mutant SOD1/Bcl-2 toxic mitochondrial complex restore mitochondrial function and cell viability in mutant SOD1-mediated ALS
  21. Selective increase of two ABC drug efflux transporters at the blood-spinal cord barrier suggests induced pharmacoresistance in ALS
  22. An over-oxidized form of superoxide dismutase found in sporadic amyotrophic lateral sclerosis with bulbar onset shares a toxic mechanism with mutant SOD1
  23. Motor neuron impairment mediated by a sumoylated fragment of the glial glutamate transporter EAAT2
  24. In vivo and in vitro determination of cell death markers in neurons
  25. Wild-type and mutant SOD1 share an aberrant conformation and a common pathogenic pathway in ALS