Thomas Jefferson University

Areas of ObGyn Research

Learn more about our key research area overviews, attendees, and funded studies.

Obstetrics

Labor & Delivery Management

At Thomas Jefferson University, we are routinely conducting clinical trials to improve labor and delivery management. These trials include induction protocols, cesarean section practices, second stage interventions. 

Faculty

Vincenzo Berghella, MD
Rebekah McCurdy, MD

Ongoing studies (Principle investigator/Funding source)

  • Cesarean Health by Incision Placement (McCurdy)
  • Inpatient vs outpatient cervical ripening (Pierce-Williams/Berghella)
  • Dilacheck, a tool to improve cervical assessment in labor (Berghella, NIH)

Preterm Birth Prediction & Prevention

Thomas Jefferson University Division of Maternal Fetal Medicine has a long history of research in the prediction and prevention of preterm birth. Our research in this area has driven the use of interventions and therapies for preterm birth prevention and helped develop national guidelines. 

Faculty

Vincenzo Berghella, MD
Jason Baxter, MD
Rupsa Boelig, MD

Ongoing Studies (Principle investigator/Funding source)

  • Vaginal vs IM progesterone for prevention of recurrent preterm birth (VIP): Boelig/Departmental Funding
  • Cerclage on Low Risk Singletons with Short Cervix (COLORS): Berghella/Departmental Funding
  • A Multicenter Assessment of a Spontaneous Preterm Birth Risk Predictor (TREETOP): Baxter/Sera Progostics
  • Azithromycin Dosing and PPROM Treatment (ADAPT): Boelig/EW Thrasher Foundation Early Investigator Grant
  • Vaginal Progesterone Pharmacokinetics in Pregnancy: Boelig/Faculty seed grant

Diabetes in Pregnancy

Both pregestational and gestational diabetes in pregnancy has a significant impact on both maternal and neonatal outcomes. Diabetes can be challenging to manage and requires intensive both maternal and fetal surveillance. Our research in diabetes in pregnancy aims to make it easier for mothers to manage diabetes in pregnancy and help us understand how best to improve outcomes for both mother and baby.

Faculty

Vincenzo Berghella, MD
Amanda Roman, MD

Ongoing Studies (Principle investigator/Funding source)

  • Use of a mobile app to improve patient glucose monitoring (Berghella/Sensyne) 

Preeclampsia & Hypertension

Preeclampsia and hypertensive disorders of pregnancy are a leading cause of both maternal and neonatal morbidity and mortality. Thomas Jefferson University Hospital is an urban tertiary care center with a high risk pregnant population. Our research in preeclampsia focuses on optimizing the prediction and prevention of preeclampsia to improve maternal and neonatal outcomes

Faculty

Amanda Roman, MD
Rupsa Boelig, MD

Ongoing Studies (Principle investigator/Funding source)

  • Universal Screening for Preeclampsia Prevention (Boelig/March of Dimes)
  • Antenatal Platelet Response on Aspirin and Correlation with Hypertensive disorders of pregnancy (APROACH) (Boelig/March of Dimes, NICHD, AMAG pharmaceutical).

Opiate Use Disorder in Pregnancy

Thomas Jefferson University has been at the forefront of opiate use disorder treatment in pregnancy for decades. The Maternal Addiction Treatment Education and Research (MATER) program is active in the clinical care and research of opiate use disorder in pregnancy

MATER is a program in the Department of Obstetrics & Gynecology at Thomas Jefferson University Hospitals, and includes the Sidney Kimmel Medical College departments of OB/GYN, Pediatrics and Psychiatry.

Faculty

Jason Baxter, MD
Diane J. Abatemarco, PhD, MSW
Dennis Hand, PhD
Vanessa Short, MPH

Ongoing Studies (Principle investigator/Funding source)