Makarand V. Risbud, PhD

Contact Dr. Risbud

1015 Walnut Street
Suite 501, Curtis Bldg.
Philadelphia, PA 19107

Most Recent Peer-reviewed Publications

  1. Long-term treatment with senolytic drugs Dasatinib and Quercetin ameliorates age-dependent intervertebral disc degeneration in mice
  2. TonEBP regulates the hyperosmotic expression of aquaporin 1 and 5 in the intervertebral disc
  3. The role of HIF proteins in maintaining the metabolic health of the intervertebral disc
  4. Development of a standardized histopathology scoring system using machine learning algorithms for intervertebral disc degeneration in the mouse model—An ORS spine section initiative
  5. Role of autophagy in intervertebral disc and cartilage function: implications in health and disease
  6. Hypoxia and Hypoxia-Inducible Factor-1α Regulate Endoplasmic Reticulum Stress in Nucleus Pulposus Cells: Implications of Endoplasmic Reticulum Stress for Extracellular Matrix Secretion
  7. Understanding embryonic development for cell-based therapies of intervertebral disc degeneration: Toward an effort to treat disc degeneration subphenotypes
  8. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1
  9. Genetic murine models of spinal development and degeneration provide valuable insights into intervertebral disc pathobiology
  10. Sox9 deletion causes severe intervertebral disc degeneration characterized by apoptosis, matrix remodeling, and compartment-specific transcriptomic changes
  11. Hypoxic Regulation of Mitochondrial Metabolism and Mitophagy in Nucleus Pulposus Cells Is Dependent on HIF-1α–BNIP3 Axis
  12. Comparison of inbred mouse strains shows diverse phenotypic outcomes of intervertebral disc aging
  13. Alterations in ECM signature underscore multiple sub-phenotypes of intervertebral disc degeneration
  14. TonEBP-deficiency accelerates intervertebral disc degeneration underscored by matrix remodeling, cytoskeletal rearrangements, and changes in proinflammatory gene expression
  15. Differential Effect of Long-Term Systemic Exposure of TNFα on Health of the Annulus Fibrosus and Nucleus Pulposus of the Intervertebral Disc
  16. Lactate Efflux From Intervertebral Disc Cells Is Required for Maintenance of Spine Health
  17. Arp2/3 inactivation causes intervertebral disc and cartilage degeneration with dysregulated TonEBP-mediated osmoadaptation
  18. Nucleus pulposus primary cilia alter their length in response to changes in extracellular osmolarity but do not control TonEBP-mediated osmoregulation
  19. NFAT5/TonEBP controls early acquisition of notochord phenotypic markers, collagen composition, and sonic hedgehog signaling during mouse intervertebral disc embryogenesis
  20. p16Ink4a deletion in cells of the intervertebral disc affects their matrix homeostasis and senescence associated secretory phenotype without altering onset of senescence
  21. A New Understanding of the Role of IL-1 in Age-Related Intervertebral Disc Degeneration in a Murine Model
  22. Discogenic Back Pain: Literature Review of Definition, Diagnosis, and Treatment
  23. RNA binding protein HuR regulates extracellular matrix gene expression and pH homeostasis independent of controlling HIF-1α signaling in nucleus pulposus cells
  24. Transgenic mice overexpressing human TNF-α experience early onset spontaneous intervertebral disc herniation in the absence of overt degeneration
  25. Expression of Carbonic Anhydrase III, a Nucleus Pulposus Phenotypic Marker, is Hypoxia-responsive and Confers Protection from Oxidative Stress-induced Cell Death