Thomas Neill

Thomas Neill,

Contact Dr. Neill

1020 Locust Street
JAH, Suite 336G
Philadelphia, PA 19107

215-503-6146

Medical School

Thomas Jefferson University, Philadelphia, PA - 2014

Fellowship

Postdoctoral Fellowship with Dr. Renato V. Iozzo, Thomas Jefferson University, Philadelphia, PA

Focus

mitophagy, autophagy, angiogenesis, extracellular matrix, breast cancer

Research & Clinical Interest

The Laboratory of Dr. Thomas Neill focuses on the intersection of mitochondrial autophagy (mitophagy), angiogenesis, and extracellular matrix (ECM) in the development and progression of breast cancer.  Specifically, we study the role of mitostatin, a tumor suppressor gene that is frequently mutated or silenced in many solid tumors, including triple negative breast carcinoma, by investigating a diverse array of in vitro systems and novel in vivo models. Mitostatin integrates and relays signals from the surrounding ECM to evoke mitophagy as a potential oncosuppressive mechanism to inhibit aberrant angiogenesis and tumorigenesis.