Elizabeth Spudich, PhD

Contact Dr. Spudich

1020 Locust Street
Suite 263D Alumni Hall
Philadelphia, PA 19107

(215) 503-4967

Most Recent Peer-reviewed Publications

  1. The identification of a novel phosphodiesterase 4 inhibitor, 1-ethyl-5-{5-[(4-methyl-1-piperazinyl)methyl]-1,3,4-oxadiazol-2-yl} -N-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-b]pyridin-4-amine (EPPA-1), with improved therapeutic index using pica feeding in rats as a measure of emetogenicity
  2. Camphor sulfonamide derivatives as novel, potent and selective CXCR3 antagonists
  3. Inhibition of invariant chain processing, antigen-induced proliferative responses, and the development of collagen-induced arthritis and experimental autoimmune encephalomyelitis by a small molecule cysteine protease inhibitor
  4. Cathepsin S expression is up-regulated following balloon angioplasty in the hypercholesterolemic rabbit
  5. The identification and characterization of the marine natural product scytonemin as a novel antiproliferative pharmacophore
  6. Scytonemin - A marine natural product inhibitor of kinases key in hyperproliferative inflammatory diseases
  7. Mammalian phospholipases A2: Mediators of inflammation, proliferation and apoptosis
  8. Modulation of human monocyte activities by tranilast, SB 252218, a compound demonstrating efficacy in restenosis
  9. Human calcium-independent phospholipase A2 mediates lymphocyte proliferation
  10. The human polo-like kinase, PLK, regulates cdc2/cyclin B through phosphorylation and activation of the cdc25C phosphatase
  11. Identification and initial characterization of four novel members of the interleukin-1 family