Gyorgy Hajnoczky, MD, PhD

Contact Dr. Hajnoczky

1020 Locust Street
Alumni Hall, Room 527
Philadelphia, PA 19107

(215) 503-1427

Most Recent Peer-reviewed Publications

  1. How do MICUs gate the mitochondrial calcium uniporter?
  2. Molecular pathophysiology of human MICU1 deficiency
  3. Oxidative bursts of single mitochondria mediate retrograde signaling toward the ER
  4. Pharmacological inhibition of the mitochondrial Ca2+ uniporter: Relevance for pathophysiology and human therapy
  5. Dysregulation of RyR Calcium Channel Causes the Onset of Mitochondrial Retrograde Signaling
  6. Mitochondrial calcium exchange links metabolism with the epigenome to control cellular differentiation
  7. IP3 receptor isoforms differently regulate ER-mitochondrial contacts and local calcium transfer
  8. Coming together to define membrane contact sites
  9. Dysregulation of Mitochondrial Ca2+ Uptake and Sarcolemma Repair Underlie Muscle Weakness and Wasting in Patients and Mice Lacking MICU1
  10. Redox regulation of ER and mitochondrial Ca 2+ signaling in cell survival and death
  11. Perturbed mitochondria-ER contacts in live neurons that model the amyloid pathology of Alzheimer's disease
  12. MICU1 Interacts with the D-Ring of the MCU Pore to Control Its Ca2+ Flux and Sensitivity to Ru360
  13. MICU1 Confers Protection from MCU-Dependent Manganese Toxicity
  14. Mitochondrial fusion and Bid-mediated mitochondrial apoptosis are perturbed by alcohol with distinct dependence on its metabolism
  15. Mitochondrial dynamics in adaptive and maladaptive cellular stress responses
  16. Endoplasmic Reticulum–Mitochondrial Contactology: Structure and Signaling Functions
  17. Molecular mechanisms of cell death: Recommendations of the Nomenclature Committee on Cell Death 2018
  18. Redox regulation of type-I inositol trisphosphate receptors in intact mammalian cells
  19. ROS Control Mitochondrial Motility through p38 and the Motor Adaptor Miro/Trak
  20. Mitochondrial Nanotunnels
  21. Recessive mutations in MSTO1 cause mitochondrial dynamics impairment, leading to myopathy and ataxia
  22. MSTO1 is a cytoplasmic pro-mitochondrial fusion protein, whose mutation induces myopathy and ataxia in humans
  23. Intracellular Ca2+ Sensing: Its Role in Calcium Homeostasis and Signaling
  24. Tissue-Specific Mitochondrial Decoding of Cytoplasmic Ca2+ Signals Is Controlled by the Stoichiometry of MICU1/2 and MCU
  25. Mitochondrial fusion dynamics is robust in the heart and depends on calcium oscillations and contractile activity